A&R: IL-13Rα1-mediated signaling regulates age-related/autoimmune B cell expansion and lupus pathogenesis

Age-related / autoimmune B cells (ABC) are an emerging subset of B cells (in addition to the classic B cell markers, they also express myeloid markers such as the transcription factor T-bet and CD11c , so these cells are also called CD11c+ T -bet+ B cells), which are abnormally expanded in SLE .

Age-related / autoimmune immune B cells (ABC) are an emerging subset of B cells (in addition to the classic B cell markers, they also express myeloid markers such as the transcription factor T-bet and CD11c , so these cells are also called CD11c+ T-bet+ B cells), which are abnormally expanded in SLE .

Mice lacking DEF6 and SWAP-70 (double knockout = DKO , SWAP-70 and DEF6 are homologous proteins that control cytoskeletal reorganization and interferon regulator activity) that preferentially develop lupus in females were compared with IL-13Rα1 KO mice hybrid

Mice lacking DEF6 and SWAP-70 (double knockout = DKO , SWAP-70 and DEF6 are homologous proteins that control cytoskeletal reorganization and interferon regulator activity) that preferentially develop lupus in females were compared with IL-13Rα1 KO mice hybrid

ABCs express higher levels of IL-13Rα1 than follicular B cells .

These studies reveal a novel role for IL-13Rα1 in controlling the generation and differentiation of ABCs , suggesting that IL-13Rα1 contributes to these roles by regulating a subset of signaling events mediated by IL-21 .

Original source:

Chen, Z.

Chen, Z.
, Flores Castro, D.
, Gupta, S.
, Phalke, S.
, Manni, M.
, Rivera-Correa, J.
, Jessberger, R.
, Zaghouani, H.
, Giannopoulou, E.
, Pannellini, T.
and Pernis, AB (2022), IL-13Rα1-Mediated Signaling Regulates Age-Associated/Autoimmune B-Cell Expansion and Lupus Pathogenesis.
Arthritis Rheumatol.
Accepted Author Manuscript.
https://doi.
org/10.
1002/art.
42146 https://doi.
org/10.
1002/art.
42146

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