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    Home > Active Ingredient News > Immunology News > A&R: In vivo multidimensional immunoassay of cutaneous lupus erythematosus stratified by patient response to antimalarial drugs

    A&R: In vivo multidimensional immunoassay of cutaneous lupus erythematosus stratified by patient response to antimalarial drugs

    • Last Update: 2022-08-12
    • Source: Internet
    • Author: User
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    Objective: The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of the inflammatory process among patient.


    Objective: The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of the inflammatory process among patient.


    Methods: We performed image-quality flow cytometry on 48 treatment-naïve skin biopsies from HCQ responders, QC responders, and non-responders (NR) to analyze multiple immune cells in the native environment of CLE skin types and inflammatory marker.


    Results: HCQ responders showed increased CD4 T cells compared to Q.


    Conclusions: These findings demonstrate that the immune composition differs between CLE patients and guide a future based on precision medicine and treatment respons.


    Source: Patel,.


    Patel,.
    , Vazquez,.
    , Chin,.
    , Keyes,.
    , Yan,.
    , Diaz,.
    , Grinnell,.
    , Sharma,.
    , Li,.
    , Feng,.
    , Sprow,.
    , Dan,.
    and Werth, VP (2022), Multidimensional immune profiling of cutaneous lupus erythematosusin vivo https://d.
    org/11002/a.
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