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    Home > Active Ingredient News > Immunology News > A&R: Low concentrations of C5a complement receptor antibodies are associated with disease activity and relapse in ANCA-associated vasculitis

    A&R: Low concentrations of C5a complement receptor antibodies are associated with disease activity and relapse in ANCA-associated vasculitis

    • Last Update: 2023-01-04
    • Source: Internet
    • Author: User
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    Objective: To detect the concentration of circulating antibodies targeting C3a and C5a complement receptors in ANCA-associated vasculitis (AAV) and to analyze their correlation
    with disease activity.

    Methods: The concentrations
    of C3a and C5a complement receptor antibodies and plasma complement fragments C3a and C5a in patients with AAV (n=110; granulomatosis with polyangiitis [GPA, n=82], microscopic polyangiitis [MPA, n=28]), systemic lupus erythematosus (SLE, n=36) and healthy donors (HD, n=220) were measured.
    C3aR and C5aR expression
    of circulating neutrophils, monocytes, and T cells were analyzed using flow cytometry.
    Clinical data
    were assessed at the time of serological sampling and during 60-month follow-up.

    Results: In AAV, anti-C3aR and anti-C5aR antibodies decreased (P = 0.
    0026 and P≤0.

    During remission, anti-C3aR antibody concentrations rise to values comparable to HD, while anti-C5aR concentrations do not

    In GPA, C5a and anti-C5aR antibody concentrations were negatively correlated with each other (r=-0.
    6831, P=0.

    In newly diagnosed GPA, a decrease in concentration of anti-C5aR antibody, rather than anti-C3aR antibody, was associated with disease activity (P = 0.

    In addition, low anti-C5aR antibodies were associated with GPA (HR: 3.
    54, P = 0.
    0009) and MPA (HR: 4.
    41, P = 0.
    0041) recurrence.

    The frequency of C5aR-expressing cells in the T cell population of the GPA group increased (CD4+ T cells: P = 0.
    0021; CD8+ T cells: P = 0.
    0118), but not
    in the MPA group.

    Conclusion: Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk of AAV recurrence.



    Klapa S, Müller A, Koch A, et al.
    Low concentrations of C5a complement receptor antibodies are linked to disease activity and relapse in ANCA-associated vasculitis [published online ahead of print, 2022 Nov 21].
    Arthritis Rheumatol.
    2022; 10.

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