A&R: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as biomarkers for axial spondylitis

OBJECTIVE: To assess the utility of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in predicting disease activity in sacroiliitis imaging and axial spondyloarthritis (axSpA) and compare it with conventional The use of tumor necrosis factor inhibitors (TNFi) was investigated in relation to these laboratory values ​​compared with inflammatory markers

METHODS: Observational data from this project were analyzed to understand long-term outcomes from the Spondyloarthritis Registry

RESULTS: The majority of study participants (n=354) were Caucasian, male, and HLAB27-positive

NLR (OR=1.

Models with traditional biomarkers including PLR performed better than models with traditional biomarkers alone

Use of TNFi reduced NLR (OR=0.

Conclusions: These findings suggest that NLR and PLR are associated with sacroiliitis and disease activity; NLR and PLR respond to TNFi treatment

Source:

https://onlinelibrary.