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Objective: Synovial fibrosis contributes to the pathology of osteoarthritis (OA) , but the underlying mechanisms remain uncle.
synovial fibrosis synovial fibrosis osteoarthritis (OA) osteoarthritis (OA) microRNA (miR)-27b-3p microRNA (miR)-27b-3p effect of miR-27b-3p on synovial fibrosis
METHODS: In situ hybridization was performed on synovial sections from Kellgren-Lawrence graded knee OA patients and knee OA (medial meniscal instability; DMM) mouse models for miR-27b-3p staining
In situ hybridization miR-27b-3p staining miR-27b-3p inhibitor
MiR-27b-3p mimic or inhibitor transfection experiments on human OA fibroblast-like synoviocytes (FL) using RT-qPCR array, RNA-sequencing, RT-qPCR, Western Blot, immunofluorescence and migration assays relevant inspectio.
Human OA fibroblast-like synoviocytes (FL) immunization
Results: MiR-27b-3p expression was increased in the synovium of knee OA patients and after DMM surgery in mi.
Induced synovial fibrosis-like phenotype with increased synovitis score and increased COL1A1 and α-SMA expression
MiR-27b-3p mimetic treatment of human OA-FLS induced profibrotic responses including increased migration and expression of key extracellular matrix (ECM) genes , whereas inhibitor transfection had the opposite effe.
Migration and expression of extracellular matrix (ECM) genes in the PPARG/ADAMTS8 signaling axis
Conclusions: This study is the first to demonstrate the critical role of miR-27b-3p and its downstream signaling mediators in ECM regulation associated with synovial fibrosis during OA
Critical role of miR-27b-3p and its downstream signaling mediators in ECM regulation associated with synovial fibrosis during OA play a key role in
Source:
Source:Tavallaee G, Lively S, Rockel JS, et .
Tavallaee G, Lively S, Rockel JS, et .
Contribution of microRNA-27b-3p to synovial fibrotic responses in knee osteoarthritis [published online ahead of print, 2022 Jul
Arthritis Rheumat.
2022;11002/a.
4228 doi :11002/a.
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