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Purpose : Myofiber necrosis is an important pathological feature of idiopathic inflammatory myopathies ( IIMs ), and the molecular mechanisms are largely unkno.
Objective Myofiber necrosis is an important pathological feature of idiopathic inflammatory myopathies ( IIMs ), the molecular mechanism of which is largely unkno.
Methods Western blotting and immunohistochemical analysis were performed to examine the expression of receptor-interacting protein 3 (RIP-3) and MLKL proteins , as well as necroptosis -related injury - related molecules in 26 IIM patients and 4 healthy contro.
Results Compared with healthy controls, the expression of RIP-3 and MLKL proteins and their phosphorylated forms were significantly increased in muscle tissue of IIM patient.
Conclusions These findings suggest that hyperactivated necroptosis leads to muscle damage in IIM , and suggest that necroptosis inhibitors may represent novel therapeutic targets for the treatment of II.
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(2022), Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathi.
Arthritis Rheumatol, 74: 1048-105https://d.
org/11002/a.
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