A series of advances have been made in the study of anti-stroke target genes.

Stroke, also known as stroke, has long ranked among the top 10 causes of stroke, a high incidence and fatality worldwide.
Asia alone accounts for two-thirds of global stroke deaths, with nearly 2,000 people dying from stroke each year in China and the top three in Western countries.
, stroke also spreads across young, middle-aged, old-age, and even children and adolescents.
Is blood stroke accounts for the vast majority of strokes, about 85 percent, and previous studies have reported that the occurrence, prevalence and mortality of isoemia stroke are influenced by sex, but few studies have been done on the gender heterogeneity of the anti-stroke target gene.
In response to this situation, Li Wenxing, Dai Shaoxing and others of Huang Jingfei Of the Kunming Institute of Zoology of the Chinese Academy of Sciences systematically analyzed the differences between the anti-stroke target gene in both male and female populations, as well as among the elderly and middle-aged populations, by integrating isohemia stroke transcriptomic data and combining the anti-stroke target genes in the Thomson Reuters Integrity database.
analysis found that the disorder genes of men with stroke were significantly different from those of normal men compared to those of normal women.
researchers compared the differences between the normal population of men and women and confirmed that the differences in the above disorders were caused by disease status rather than gender.
Through KEGG rich analysis, it was found that stroke patients in both men and women showed severe immune-related path path road damage, further revealing that a large number of immune-related target genes showed opposite expression trends in both men and women (e.g. IL1A, IL6, IL8, etc.).
, these target genes vary widely among people of different ages.
there are already a number of drugs targeting these target genes on the market or in the development stage.
, the gender and age heterogeneity of stroke need to be taken into account in future stroke treatment.
this study has some guiding significance for basic research and clinical trials of isoemia stroke in the future.
Stroke as a high incidence, no obvious symptoms before the onset of sudden syndrome, whether for acute interventional treatment of stroke, or later restorative treatment requires a lot of financial and energy, social and patient families to create a great burden.
, it is important to constantly explore effective anti-stroke drugs and their anti-stroke mechanisms for the treatment and recovery of stroke.
chinese traditional Chinese medicine database records more than 2,000 medicinal plants.
medicinal plants have been used to treat a variety of diseases, including stroke, for nearly a thousand years.
, however, it is a large, complex and expensive and time-consuming process to systematically explore the effective small molecular compounds and their mechanisms of action in traditional Herbal plants.
In view of this current situation, the research team Liu Jiaxuan, Dai Shaoxing and others obtained 2355 candidates for stroke compounds from 21940 small molecule compounds recorded in the Taiwan Chinese Herbal Medicine Database, the anti-stroke target gene in the Thomson Reuters Integrity database, and all the drug structures of DrugBank by screening Chinese medicine for clinical anti-stroke treatment.
1564 small molecules single target 15 anti-stroke targets, 791 small molecules belong to multi-target compounds (2-11 targets, respectively).
and 35 candidate compounds were screened by drug-resistant ADMET, with good solubility, intestinal absorption and other characteristics.
the study predicted a large number of natural anti-stroke compounds and explained the potential mechanisms of action of a variety of anti-stroke plants, providing an attractive starting point and a broad range for the development of anti-stroke drugs.
the study was published in TheErJ and Scientific Reports.
the study was supported by the "973" research program, the National Natural Science Foundation of China.
.