A special subset of immune cells can reduce kidney damage

A research team led by LMU biologist Barbara Schraml has demonstrated that a special immune cell subtype can protect the kidneys from toxin damage

The immune system is very complicated

With the help of a new mouse model, Barbara Schraml and her colleagues at LMU's Biomedical Center have now demonstrated that a unique subpopulation of mononuclear phagocytes protects the kidney from toxic damage

Different organizational sources, yes, but different functions?

"There are several precursors that can produce these immune cells, but they all differentiate into cells that look very similar," Schraml said

To test this idea, she began to selectively consume each different subtype of mononuclear phagocytes in the kidney

A new mouse model reveals the special properties of mononuclear phagocytes

To clarify the reason for this difference, she developed a mouse model that allows different subtypes of MNPs to be specifically knocked out in the kidney

Schraml now plans to study the function of CD64-positive immune cells in the kidney from a different perspective

Proceedings of the National Academy of Sciences

DOI

10.