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A, enanthate testosterone or cyclic pentyl propionate
A, enanthate testosterone or cyclic pentyl propionate1.
2.
3.
2
4.
5.
2.
2.
2.
3.
2
4.
5.
child
Third, testosterone transdermal patch
Third, testosterone transdermal patch1.
2.
3.
2
4.
5.
Four, oral testosterone adhesion tablets
Four, oral testosterone adhesion tablets1.
Usage: 30mg controlled release, bioadhesive tablets, 2 times a day
2.
Pharmacokinetic characteristics: absorbed from buccal mucosa
3.
DHT and E 2 : restore T or DTH levels to normal in male patients with hyposexual function
4.
Advantages: correct androgen deficiency symptoms in healthy men with low gonadal hormone levels
5.
Disadvantages: 16% of men receiving treatment have glue-related adverse events
Five, testosterone implants
Five, testosterone implants1.
Usage: 2-6 small spheres are implanted into SC, the dosage and schedule vary with the preparation
2.
Pharmacokinetic characteristics: Serum T peak appears in the first month and remains normal for 3-6 months, depending on different preparations
3.
DHT and E 2 : T/DTH and T/E2 levels remain unchanged
4.
Advantages: correct symptoms of androgen deficiency
5.
Disadvantages: the need for surgical implantation of the ball, the ball has the risk of prolapse
6.
17 Alpha - Methyltestosterone
17 Alpha - Methyltestosterone
1.
Usage: This 17α-alkylated compound should not be used due to potential liver toxicity
2.
Pharmacokinetic characteristics: oral activity
3.
Disadvantages: different changes in clinical response; potential liver toxicity
Seven, oral testosterone undecanoate
Seven, oral testosterone undecanoate1.
Usage: 40-80mg taken orally with meals, 2 times a day or 3 times a day
2.
Pharmacokinetic characteristics: when processed by oil, it is absorbed into the portal system through the lymphatic vessels, and there are great differences between individuals and within individuals
3.
DHT and E 2 : T/DTH level rises
4.
Advantages: convenient oral administration
5.
Disadvantages: Not yet on the market in the United States, changeable clinical response, changeable serum T level, high DTH/T
8.
Long-acting testosterone undecanoate for injection
Long-acting testosterone undecanoate for injection
1.
Usage: European dosage regimen: 1000 mg intramuscular injection, 1000 mg again 6 weeks later, 1000 mg every 10-14 weeks thereafter
2.
Pharmacokinetic characteristics: When 750-1000 mg is administered by intramuscular injection, the serum T level remains normal in most men receiving treatment
.
3.
DHT and E 2 : DHT and E2 increase in proportion to serum T, and the ratio of T/DTH and T/E2 remains unchanged
.
4.
Advantages: It corrects the symptoms of androgen deficiency and does not require frequent administration
.
5.
Disadvantages: a large dose of intramuscular injection (4ml) is required, and a small number of patients have cough after administration
.
Nine, testosterone binder matrix patch
Nine, testosterone binder matrix patch1.
Usage: 2X60cm 2 patch can provide 4.
8mgT/d
2.
Pharmacokinetic characteristics: make T, DTH and E2 levels reach the physiological range
3.
DHT and E 2 : The ratio of T/DTH and T/E2 is within the physiological range
.
4.
Advantages: maintain for 2 days
5.
Disadvantages: sometimes allergies
Original source
Dennis L.
Kasper, Anthony S.
Fauci, Stephen L.
Hauser, et al, HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 19th Edition.