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    Home > Active Ingredient News > Endocrine System > A summary of testosterone replacement therapy drugs

    A summary of testosterone replacement therapy drugs

    • Last Update: 2021-09-19
    • Source: Internet
    • Author: User
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    A, enanthate testosterone or cyclic pentyl propionate

    A, enanthate testosterone or cyclic pentyl propionate

    1.


    2.


    3.


    2

    4.


    5.


    2.


    2.


    2.


    3.


    2

    4.


    5.


    child

    Third, testosterone transdermal patch

    Third, testosterone transdermal patch

    1.


    2.


    3.


    2

    4.


    5.


    Four, oral testosterone adhesion tablets

    Four, oral testosterone adhesion tablets

    1.
    Usage: 30mg controlled release, bioadhesive tablets, 2 times a day

    2.
    Pharmacokinetic characteristics: absorbed from buccal mucosa

    3.
    DHT and E 2 : restore T or DTH levels to normal in male patients with hyposexual function

    2

    4.
    Advantages: correct androgen deficiency symptoms in healthy men with low gonadal hormone levels

    5.
    Disadvantages: 16% of men receiving treatment have glue-related adverse events

    Five, testosterone implants

    Five, testosterone implants

    1.
    Usage: 2-6 small spheres are implanted into SC, the dosage and schedule vary with the preparation

    2.
    Pharmacokinetic characteristics: Serum T peak appears in the first month and remains normal for 3-6 months, depending on different preparations

    3.
    DHT and E 2 : T/DTH and T/E2 levels remain unchanged

    2

    4.
    Advantages: correct symptoms of androgen deficiency

    5.
    Disadvantages: the need for surgical implantation of the ball, the ball has the risk of prolapse

    6.
    17 Alpha - Methyltestosterone

    6.
    17 Alpha - Methyltestosterone

    1.
    Usage: This 17α-alkylated compound should not be used due to potential liver toxicity

    2.
    Pharmacokinetic characteristics: oral activity

    3.
    Disadvantages: different changes in clinical response; potential liver toxicity

    Seven, oral testosterone undecanoate

    Seven, oral testosterone undecanoate

    1.
    Usage: 40-80mg taken orally with meals, 2 times a day or 3 times a day

    2.
    Pharmacokinetic characteristics: when processed by oil, it is absorbed into the portal system through the lymphatic vessels, and there are great differences between individuals and within individuals

    3.
    DHT and E 2 : T/DTH level rises

    2

    4.
    Advantages: convenient oral administration

    5.
    Disadvantages: Not yet on the market in the United States, changeable clinical response, changeable serum T level, high DTH/T

    8.
    Long-acting testosterone undecanoate for injection

    8.
    Long-acting testosterone undecanoate for injection

    1.
    Usage: European dosage regimen: 1000 mg intramuscular injection, 1000 mg again 6 weeks later, 1000 mg every 10-14 weeks thereafter

    2.
    Pharmacokinetic characteristics: When 750-1000 mg is administered by intramuscular injection, the serum T level remains normal in most men receiving treatment
    .

    3.
    DHT and E 2 : DHT and E2 increase in proportion to serum T, and the ratio of T/DTH and T/E2 remains unchanged
    .

    2

    4.
    Advantages: It corrects the symptoms of androgen deficiency and does not require frequent administration
    .

    5.
    Disadvantages: a large dose of intramuscular injection (4ml) is required, and a small number of patients have cough after administration
    .

    Nine, testosterone binder matrix patch

    Nine, testosterone binder matrix patch

    1.
    Usage: 2X60cm 2 patch can provide 4.
    8mgT/d

    2

    2.
    Pharmacokinetic characteristics: make T, DTH and E2 levels reach the physiological range

    3.
    DHT and E 2 : The ratio of T/DTH and T/E2 is within the physiological range
    .

    2

    4.
    Advantages: maintain for 2 days

    5.
    Disadvantages: sometimes allergies

    Original source

    Dennis L.
    Kasper, Anthony S.
    Fauci, Stephen L.
    Hauser, et al, HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 19th Edition.

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