echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > A treatment that reduced bad cholesterol by 61% In animal experiments with gene editing therapy showed lasting results

    A treatment that reduced bad cholesterol by 61% In animal experiments with gene editing therapy showed lasting results

    • Last Update: 2021-01-22
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit
    HeFH affects about one in every 200 to 500 people worldwide.
    patients usually carry a mutation in the LDLR gene, which causes a decrease in LDLR expression and elevates LDL-C levels in the blood.
    over time, high LDL-C accumulates in the arteries of the heart, causing blood flow to decrease or block, eventually leading to a heart attack or stroke.
    previous studies have shown that PCSK9 gene infestion can increase LDL-patient expression, leading to lower LDL-C levels and reducing the risk of coronary heart disease.
    VERVE-101 causes the PCSK9 gene to inferces by altering the DNA genetic sequence of PCSK9 by a single A-to-G.
    latest data have shown that monobase editing of the PCSK9 gene in the livers of non-human primates can consistently reduce levels of LDL-C in the blood and PCSK9 proteins in the blood.
    study, a single intravenous infusion reduced blood LDL-C by 59% in week 2 and was maintained within 6 months of treatment.
    LDL-C decreased by an average of 61% over that time period.
    the average blood PCSK9 protein level decreased by 89% over the same six-month period.
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.
    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent Echemi's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.