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AACR's blockbuster SPOTLIGHT203 trial: efficacy of intratumoral injection of BO-112 combined with pembrolizumab in patients with advanced melanoma resistant to PD-1 immunotherapy

 Last Update: 2022-05-18
 Source: Internet
 Author: User

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BO-112 is a double-stranded synthetic RNA formulated from polyethyleneimine that mimics viral infection

Recently, experts from the Gregorio Marañón University General Hospital in Madrid, Spain designed a phase 2 trial and the results were presented at the AACR2022 meeting

This is a single-arm study (NCT04570332) of intratumoral BO-112 and intravenous pembrolizumab in patients with melanoma (skin, condyloma, or mucosa) receiving anti-PD1 therapy and confirmed progressive disease (PD)

Results There were 42 subjects; 43% were female; median age was 66 years

Four patients with baseline LDH>3xULN progressed no later than Week 8

In conclusion, the primary efficacy endpoint of the study has been met

source:

https://#!/10517/presentation/20156

https://#!/10517/presentation/20156 https://#!/10517/presentation/20156

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