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Abamectin drug residue determination method (3)

 Last Update: 2021-10-22
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(4) Liquid chromatography-mass spectrometry (LC-MS)

Due to the limitation of detector selectivity, the HPLC method has the disadvantage of relatively low sensitivity
.

With the rapid development of electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) technologies, single quadrupole (MS), ion trap (MSn), triple quadrupole (MS/MS), time of flight (TOF), etc.

Figure 21-2 The main cracking pathways of IVM

1) Liquid chromatography-single-stage mass spectrometry (LC-MS)

The early reports of AVMs confirmation technology mainly use the LC-MS method, and mainly use the APCI source
.

Heller et al.

2) Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

LC-MS/MS can use three ionization sources: APCI, ESI and APPI
.

A.
APCI source

Howells et al.
established a method for quantification and confirmation of AVMs in cattle liver
.

In order to facilitate the formation of anions, the analytes are separated by LC at alkaline pH, APCI ionization negative ion mode monitoring, MSn multi-stage mass spectrometry analysis, each parent ion monitors 2 product ions

The CCB of EPR, AVM, DOR, MOX and IVM were 3.
1ng/g, 3.
2ng/g, 2.
2ng/g, 4.
0ng/g and 3.
2ng/g, respectively, and the average recovery rates were 70.
9%, 69.
1%, 65.
9 %, 69.
7% and 73.
2%, RSD is 11.
6%, 3.
9%, 6.
4%, 9.
3% and 10.
5%
.

Campillo et al.

B.
ESI source

ESI is currently the most commonly used ionization method in the LC-MS analysis of AVMs
.

Hino et al.
used ESI positive ion mode to detect AVM, IVM, EPR, DOR and MOX residues in beef liver
.

The analytes were separated by TSK-GEL ODS 100V chromatographic column, acetonitrile and 0.

Dahiya et al.

established analytical methods for IVM, DOR and MOX in milk

Wang et al.
established methods for the determination of AVM, IVM, DOR and EPR in pork, pork liver, fish and milk
.

The analytes are separated by UPLC, detected in ESI ionization, positive ion, and MRM mode, and the entire analysis time is within 3.

C.
APPI source

Turnipseed et al.
reported the use of LC-MSn multi-stage mass spectrometry to detect EPR, IVM, DOR, and MOX residues in milk
.

The sample was extracted with acetonitrile, cleaned up by C ₁₈ column, and detected by LC-MSn

Related Links: Methods for Determination of Abamectin Drug Residues (2)

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