About the esterification reaction of amino acids.

:
I have synthesized more than 10 kinds of
amino acids
esters, the initial summary of the esterification reaction of amino acids is as follows:
1, the use of waterless HCl as a catalyst, into the HCl to amino acid alcohol solution, pay attention to prevent blockage of the trachea, and then return for half an hour, cooling, desulfurizing solids, filtering out, alkylate hydrochloride. Then add to chloroform, then add NaOH solids, stirring, TLC detection, filter out solids, filter fluid spin dry, that is, amino acid esters.
:
I have also synthesized more than a dozen amino acid methyl esters, using the following methods:
in the ice bath conditions to waterless methanol drop chlorinated metformin, after the ground naturally heat up, room temperature stirring 1. 5 to 2. 0 hours after the ice bath to add amino acids, stirring for two days or so after steaming off the solvent, many times a small amount of methanol with residual hydrogen chloride gas, and finally the amino acid methylate hydrochloride. Use triethylamine or nitroethyl to meso-mesalyzepine.
:
1, amino acids generally insoluble in the alcohol solution, after passing hydrochloric acid gas into amino acids hydrochloric acids,
heating
generally dissolved in alcohol, amino acid esters hydrochloric acid is more soluble in alcohol, the reaction is one
phase

.