Absorption and metabolism of Ginsenoside
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Last Update: 2020-04-03
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Source: Internet
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Author: User
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2015-01-25 classification: the active ingredients of ginsenoside, ginsenoside, volatile oil, organic acid and polypeptide have been found Ginsenoside is the most important active substance in ginseng According to different aglycones, ginsenosides can be divided into three groups: protopanaxadiol, protopanaxatriol and oleanolic acid The saponins composed of the first two aglycones have physiological activity, while the latter one has no physiological activity The aglycones of ginsenoside ra1, ra2, Rb1, Rb2, RB3, RC and RD are protopanaxadiol; the aglycones of ginsenoside Re, RF, Rg1, RGz, Rh1 and 20 monoglucosyl RF are protopanaxatriol; the aglycones of ginsenoside ro are oleanolic acid Ginseng can significantly reduce the oxygen consumption of the body, reduce the fatigue in the process of brain excitation, make the utilization of glycogen and high-energy phosphorylation more economical, prevent the accumulation of lactic acid and pyruvate, and make its metabolism more complete The results showed that ginsenoside Rb1, Rb2, RC, RD, re, RF and RGI could significantly increase the spontaneous activity of mice after forced walking (1) The absorption and metabolism of Ginsenoside Rg1 showed that ginsenoside Rg1 could be absorbed rapidly in the upper digestive tract of rats The absorption amount of Osmunda accounted for 1.926-20.0% of the dosage of Ginsenoside Rg1 Rg1 can be partially decomposed in the rat stomach, and the decomposition products are the same as those of RGI in mild acid hydrolysis (0.1mol/l HCl, 37 ℃) The concentration of Rg1 in serum reached the peak value 30 min later Within 1.5h, Rg1 reached the maximum concentration in all tissues of rats But Rg1 was not found in the brain The ratio of Rg1 secretion into urine and bile of rats was 2:5 The results showed that RGI was not significantly metabolized in liver tissue, mainly in stomach and intestine of rats Ginsenoside Rg1 can be decomposed into 20 (R, s) Rh1 hydrate derivatives and F1 by tetracycline sensitive bacteria and tetracycline resistant bacteria in large intestine The results showed that the distribution of Rg1 in various organs (VG / g tissue) was 2.32 in liver, 4.60 in kidney, 2.65 in heart, 4.65 in lung, 4.90 in spleen, 55.0 in stomach, 15177.0 in small intestine, 51.60 in large intestine and 0.4 μ g / ml in serum It is also reported that Rg1 is mainly excreted in the body through bile (2) The absorption and metabolism of ginsenoside Rb1 has been reported that the absorption and distribution of ginsenoside Rb1 in the body is different from that of Rg1 after intragastric or intravenous injection of ginsenoside Rb1 The absorption of ginsenoside Rb1 in the digestive tract of rats after intragastric administration (100mg / kg) is very small The results showed that ginsenoside Rb1 was decomposed only in a small amount in rat stomach, and its decomposition products were different from those of RB1 in mild condition After intravenous injection of ginsenoside Rb1 (5mg / kg), the TL / 2 of RB1 decreased for 14.5h It is speculated that the concentration of ginsenoside RBI in serum and tissue of rats can be maintained for a long time after intravenous injection, which may be due to the binding of RB1 and plasma protein RB1 can be excreted into urine gradually, but there is no RB1 in bile RB1 absorbed at the end of digestive tract is mainly rapidly decomposed or metabolized in large intestine RB1 can be decomposed into RD and other two products by intestinal enzymes and tetracycline resistant bacteria in large intestine In addition, Rb2 was reported to be treated with 0.1mol/l HCl equivalent to the acidity of gastric juice, and part of Rb2 was hydrolyzed to 20 (R, s) - ginsenoside RB3 However, Rb2 is rarely decomposed in the rat stomach, and the metabolites in the stomach are different from those hydrolyzed in 0.1mol/l HCl Four Rb2 derivatives, 24 hydroperoxy-25-ene-rb2, 25 hydroperoxy-23-ene - Rb2, 24 hydroxy-25-ene-rb2 and 25 hydroxy-23-ene-rbz, were isolated and identified from their gastric metabolites.
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