At 11 o'clock yesterday morning, in a large office in the Department of Hematology of Ruijin Hospital affiliated to Shanghai Jiaotong University, a table of medical experts was waiting for someone- Wang Zhenyi , a 97-year-old academician of the Chinese Academy of Engineering
academician I saw the old man walking in vigorously on crutches, and happily said to Professor Wang Chaofu, the director of the pathology department: "Doctor Wang, I just saw the patient.
This scene is not an ordinary expert consultation, but the site of the famous "open-book exam" every Thursday in the Department of Hematology of Ruijin Hospital-it is not someone else who takes the exam, it is Academician Wang Zhenyi himself
academician Wang Zhenyi, who is both a doctor and a teacher, asked students to "test" him with the most difficult cases encountered in clinical practice every week
On the occasion of Teacher's Day this year, the reporter came to the "examination site" yesterday to listen to this special teacher-student dialogue
"More important than the answer is the process of finding the answer"
"More important than the answer is the process of finding the answer" In Ruijin Hospital, Academician Wang Zhenyi 's "open-book examination" is too famous
academician Take yesterday's "open-book exam" as an example.
Castleman’s disease, also known as giant lymphadenopathy or angiofollicular lymphadenopathy, is only a possibility for the diagnosis of this case
academician What's interesting is that the old man does not "hand in the paper" immediately
In layman's eyes, it seems to be an easy greeting between doctors and patients, and the second expert to understand, "Wang in the rounds, looking for clues, verify the answer in my mind"
Sure enough, after Wang Zhenyi returned to the conference room, he did not forget to explain to the students: "Pathological diagnosis is definitely not just looking at the microscope, it must be combined with the clinic!" "There used to be a pathologist in our hospital.
Unknowingly, the clock was pointing to 12 o'clock, ushering in the time of "handing in papers": Wang Zhenyi considered that this is Kimura disease, and further analyzed the treatment ideas with the students, "it may become T-cell lymphoma later, requiring close follow-up
"Mr.
Academicians create special ward rounds, and colleagues across the country "seeking links"
Academician own special rounds, fellow country "seeking link" Fellow "I can still do some work while studying and selling land for the time being
Wang Zhenyi is a well-known hematologist in China and the winner of the country's highest science and technology award
Acute promyelocytic leukemia used to be the most dangerous type in the leukemia family, and many patients often died within a few hours of rescue
.
Until the 1980s, there was no effective treatment for it worldwide
.
"It was very frustrating to watch the patients pass away one by one
.
" Wang Zhenyi recalled.
At that time, under very limited conditions, they heard about "inducing differentiation
.
" However, no one knows how to "induce and differentiate" tumor cells into good cells
.
The scientific research of the Department of Hematology of Ruijin Hospital started from a small laboratory
.
Through the "heard", Wang Zhenyi learned that there is an amino acid that may allow tumors to "rectify the evil and induce differentiation," and he took the students to invest in the research
.
In the meantime, they have experienced many failures and walked into "dead alleys" time and time again
.
Later, Wang Zhenyi led graduate students through a series of experiments and discovered that all-trans retinoic acid, the oxide of vitamin A, can transform naive leukemia cells into mature cells in in vitro experiments
.
With this discovery, everyone was ecstatic
.
However, this is an in vitro experiment after all
.
In 1986, they finally waited for patient "001"
.
The Department of Hematology of Shanghai Children's Hospital admitted a 5-year-old child in critical condition
.
"A dead horse is a living horse doctor!" With the determination of the family, this new treatment plan was put into practice
.
This patient was finally cured, survived, married and had children!
This is the first successful case in which the theory of induced differentiation allowed cancer cells to "change the evil and return to the right"
.
In 1988, Wang Zhenyi's related results were published in the "Blood" magazine.
This paper was later rated as one of the 86 papers with the highest citation rate and the most influential in the world in a century
.
Since then, Wang Zhenyi and students Chen Zhu, Chen Saijuan, Chen Guoqiang, etc.
, creatively proposed the "all-trans retinoic acid combined with arsenic trioxide" treatment method, making this acute promyelocytic leukemia, once regarded as the most dangerous leukemia, become the world's most dangerous leukemia.
The first leukemia that can be cured
.
This method of treatment is sea foreign media hailed as a body "Shanghai plan", and inventions such as artemisinin listed as "20th century New China, the world's eight major contributions to medical science"
.
Accordingly, Wang Zhenyi won the Kettering Award, the highest award in the international oncology community.
The jury called Wang Zhenyi "the first person in the history of human cancer treatment to successfully apply differentiation therapy
.
"
Foreign media It is such a well-known international medical scholar who created a special round of ward rounds-the "open-book examination" after all the administrative positions were "assigned" in 2003, that is, the students submit clinical encounters every Monday.
Difficult cases form "examination papers"
.
In the next week, Wang Zhenyi will search the world's latest literature, comprehensively think about it, analyze and "answer the paper" based on years of experience in consultation, and discuss it with everyone every Thursday
.
The "open-book exam" is 18 years old
.
In 2020, the new crown epidemic will ravage the world
.
On May 15th, 96-year-old Wang Zhenyi and his student Li Junmin used the “Xiaoxue” robot equipped with 5G technology in the Department of Hematology of Ruijin Hospital to connect with a 74-year-old patient in the “cloud” to continue his “answer time”
.
At that time, the epidemic situation was still relatively severe.
Watching the teacher communicate with patients online without distraction, watching hundreds of documents compiled by him in two or three days, and using red lines to remind students to pay attention, Li Junmin was very emotional, "Can you I feel Teacher Wang's heartfelt care and love for medicine and patients
.
"
"Why does he want to do this? If he just likes to explore the unknown, he can't learn it by himself? But he insists on teaching what he has learned to students, insisting on the'open-book examination' to let young people participate in the discussion, this is A lively teaching process
.
He not only tells his students his own conclusions, but more importantly, he tells everyone without reservation how he combined literature searches, various test results, clinical manifestations, etc.
, to come up with a direction.
This is really training The best way to be a doctor
.
" Li Junmin told reporters that the cases used for the "open-book exam" were originally only in the Hematology Department of Ruijin Hospital, and later expanded to the hospital hematology medical consortium
.
Later, more and more colleagues began to "seeking links" and wanted to watch "live broadcast"
.
Because of this, the treatment experience of "Ruijin Blood" is like a seed, spreading to more and more places, benefiting the majority of patients
.
Has a profound impact on posterity, "Focus on undesirable diseases"
Has a profound impact on posterity, "Focus on undesirable diseases" After yesterday's "open-book exam", the students prepared a small surprise for Wang Zhenyi-sending flowers and cakes to wish him a happy Teacher's Day
.
"On the day before Teacher's Day, Teacher Wang called himself a'student' in front of us and accepted our'open-book examination', which is really touching and emotional
.
" Li Junmin said, Wang Zhenyi once summarized his life.
" Three books"
.
One is in the 1950s when he was engaged in the study of blood coagulation mechanism and invented the local technology for hemophilia detection; the other was in the 1980s, using all-trans retinoic acid to treat acute promyelocytic leukemia; the other is still continuing to this day The "open book exam"
.
The "Discussion Collection of Difficult Cases in the Department of Hematology of Ruijin Hospital" compiled and summarized by the "open-book examination" has been repeatedly updated and reprinted, and it has become a must for medical juniors in their clinical work
.
"Ms.
Wang is 97 years old, and he still puts himself in the position of a student.
He has set an example for us
.
Each of our doctors should always regard themselves as a student
in their hearts .
In the process of teaching and educating people, we must continue to enhance learning, continue to examine and improve ourselves
.
"Vice Ruijin hospital dean , a professor of hematology experts ZHAO-hand with emotion, said Wang Zhenyi academician every time accept the" open book exam ", also in a time inspires everyone around him young doctors learn more Facing one's "examination" well means taking every case seriously, constantly summarizing and researching, especially paying attention to those "not good diseases" and constantly searching for answers
.
Dean Academician Zhao Weilai said that she deeply understood the three degrees of medicine from Teacher Wang: "One is the level of medicine, which is the level of treatment that people care about; the second is the depth of science.
It should not be looked at by the appearance of disease, but should be explored.
The essence of the disease; the third is the humanistic temperature, we must care for each patient, this is the basic code of conduct as a doctor
.
"
There are many young people affected by the "open-book examination"
.
Li Xiaoyang, a young doctor born in the 1980s in the Department of Hematology, Ruijin Hospital, returned from aid to Tibet.
He told reporters that during the aid to Tibet last year, a young girl was diagnosed with acute promyelocytic leukemia.
With the help of the telemedicine system and the support of all parties, The all-trans retinoic acid drug developed by Mr.
Wang was shipped to Tibet
.
The girl took this special medicine within 48 hours after the diagnosis, and her condition resolved
.
"Ms.
Wang is an old gentleman who is advancing with the times.
At that time, he provided diagnosis and treatment plans for patients online through remote connection
.
" Li Xiaoyang also told reporters that just before this year's Teacher's Day, on September 6, he went to Wang After visiting the teacher’s home, it was found that the eighth batch of Chinese People’s Volunteers’ repatriation ceremony was playing on the TV set in the old man’s home
.
What Li Xiaoyang did not expect was that Wang Zhenyi had also participated in the War of Resisting the United States and Aid Korea!
In April 1953, Wang Zhenyi joined the fifth batch of Shanghai Volunteer Medical Team to Resist US Aid Korea and served as the attending physician in the touring medical team of the Northeast Military Region.
He went to the Rear Hospital of Boli County, Heilongjiang to treat the wounded
.
At that time, the rear hospital discovered a strange disease that had never been seen before
.
Many soldiers had symptoms such as hemoptysis and headache, and were diagnosed with tuberculosis accompanied by tuberculous meningitis, but they did not get better after the symptomatic medication
.
"Ms.
Wang discovered that soldiers often eat local fish and shrimp to improve their diet.
The symptoms are very similar to the symptoms of paragonimiasis he has seen in the literature
.
After blood tests, he really found paragonimiasis eggs! This discovery helped the entire army.
He cured a large number of sick soldiers in time.
Therefore, he was recorded as a second-class merit by the Northeast Military Command of the Chinese People's Liberation Army
.
" Li Xiaoyang said that while admiring Teacher Wang's superb medical skills, this past event also inspired young doctors, usually more.
Accumulation can react and be useful at critical moments
.
crucial moment Solving problems-this is the source of Wang Zhenyi's unremitting exploration of medical innovation throughout his life
.
"Sometimes there are questions that I can't answer, and I feel sad if I can't find the'answer', and I think about it all the time.
Sometimes when I think about it in the middle of the night, I get up and turn on the computer to check and find the answer
.
" Wang Zhenyi once said embarrassedly.
In order to "answer the question", I wrestled twice in the middle of the night
.
Nanny also advised him, "over 90 years of age, not to the middle of the night, too dangerous"
.
But Wang Zhenyi was unmoved, "You may forget it when you wake up during the day
.
This is a person's life, how can you not get up and quickly write it down and check it!"
Every time the "answer" is over, Academician Wang Zhenyi is always happy, smiling like a child, and pulling the young doctors around him, as if to "be affirm": "Look, I don't want to be a student first, how can I How about being a good teacher and a good doctor?"
academician
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
