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    Home > Active Ingredient News > Drugs Articles > According to the operation mode of the reactor, it can be divided into intermittent operation, continuous operation and semi intermittent operation.

    According to the operation mode of the reactor, it can be divided into intermittent operation, continuous operation and semi intermittent operation.

    • Last Update: 2020-01-03
    • Source: Internet
    • Author: User
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    According to the operation mode of the reactor, it can be divided into continuous operation, intermittent operation and semi intermittent operation The reactor with continuous operation is called continuous reactor The characteristic of this operation mode is that the raw materials are continuously transported to the reactor, and the reaction products continuously flow out of the reactor The composition of reactants in any part of the reactor does not change with time, so the continuous operation reactor is mostly a steady-state operation The continuous operation reactor has the advantages of stable product quality and high production efficiency, which is suitable for mass production In particular, it can overcome the shortcomings of the cell reaction, which can only be carried out in a limited period of time due to the depletion of nutrient matrix or the accumulation of harmful metabolites For continuous operation, new matrix can be continuously added to the reactor at a certain flow rate, and the reaction liquid can be continuously taken out at the same time with the interphase flow rate, so as to continuously supplement the nutrients required by the cell, while the harmful metabolites are continuously diluted and discharged, and the biochemical reaction can continue stably However, the continuous operation is easy to produce contamination of bacteria, and the operation time is too long, and the cells are easy to degenerate and mutate Batch operation is also called batch operation, and the reactor adopting this operation mode is also called batch reactor In the whole reaction process from the beginning to the end of the reaction, there is no substrate and product addition and output in the batch reactor with enzyme as catalyst In the reaction process, the substrate concentration and product concentration only change with the reaction time The batch reactor with cell as catalyst is sterilized (or sterilized culture medium is added in the sterilized reactor) after adding reaction matrix, inoculated and maintained certain reaction conditions After inoculation, besides aerobic reaction, the sterile air is removed, the defoamer used in foam is removed, and the acid and base used to maintain certain pH value are added No reaction is added to the substrate and no product is produced during the reaction After the reaction is carried out to a certain degree, the whole enzyme is released and postprocessing is performed After the reactor is cleaned and sterilized, human culture medium is added again to continue the reaction In this reaction process, the concentration of matrix, product and cell will change with the time of the reaction, especially the cell itself will go through different growth stages, showing no problem of catalytic activity Therefore, the basic characteristics of the batch reactor are: the reaction materials are added one time and discharged one time; the composition of the reactor system only changes with time Therefore, it belongs to an unsteady process Because the batch reactor is suitable for the reaction process of many varieties, small batch and slow reaction rate, and it can often carry out sterilization operation, so it plays an important role in the biochemical reactor Semi intermittent and semi continuous operation refers to the operation that only one of the raw materials and products is continuously transported or exported, while the rest is batch added or exported The corresponding reactor is called semi intermittent reactor or semi continuous reactor Semi intermittent operation is a kind of operation with some characteristics of both intermittent operation and continuous operation Semi intermittent operation is very important for biochemical reaction 6 for example, there is a cell reaction with matrix inhibition When the matrix concentration is too high, it will inhibit the growth of cells If semi intermittent semi continuous operation is used, the matrix concentration can be controlled at a low level to relieve its inhibition For cell reaction, this semi intermittent and semi continuous operation is often called fed batch culture, or flow addition operation technology In the process of this operation, the volume of the reaction liquid increases gradually due to the feeding, and the reaction liquid should be discharged from the reactor at a certain time If only part of the reaction liquid is taken out, the rest of the reaction liquid will continue to be fed and cultured, and the feeding and feeding operations will be carried out repeatedly This method is also called repeated feeding or repeated flow adding operation.
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