Accounts of chemical research: synthesis and application of boric acid affinity materials -- from selectivity to bionic specificity

Boron affinity materials have made remarkable progress in the past ten years, and the research group of Professor Liu Zhen of Nanjing University has made systematic and in-depth research in this field In view of the limitations of conventional boron affinity materials, the team started with the synthesis and screening of boron affinity ligands, clarified the molecular interaction mechanism and structure performance relationship related to boron affinity, put forward strategies to enhance affinity and selectivity, and developed a series of boron affinity materials with advanced performance successively, which overcame the difficulties of conventional boron affinity materials Due to the limitation of physical pH condition and low concentration target recognition in complex sample system, the boron affinity materials obtained have been successfully applied in the fields of affinity separation, histochemistry research and aptamer screening Interaction between boric acid and CIS glycol compounds (source: accounts of Chemical Research) By combining boron affinity interaction with molecular imprinting technology, the team further developed a number of convenient, universal and efficient molecular imprinting methods to prepare a series of boron affinity imprinting materials with excellent molecular recognition performance; in particular, boron affinity controlled directional surface imprinting method can predict the best imprinting time by using the molecular size of the template, and the immunogenicity is poor, and it is difficult for antibody The target molecules, such as glycan, can be easily prepared by using this technology to obtain the corresponding molecularly imprinted polymer, which will push the molecularly imprinted technology to a new height The molecular imprinting technology developed by the team can be combined with various advanced materials such as quantum dots, mesoporous nanomaterials and plasmon materials to obtain bionic recognition materials with advanced functions These biomimetic recognition materials have been widely used in the fields of disease diagnosis, post-translational modified protein identification, cancer cell targeted recognition and single cell analysis Through (a) ring opening polymerization and (b) molecular self-assembly to form a joint boric acid affinity (source: accounts of Chemical Research) paper link: accounts of chemical research http://pubs.acs.org/doi/abs/10.1021% 2fas.accounts.7b00179