"ACS AMI" from the research group of Professor Li Sanming of Shenyang Pharmaceutical University: Biocompatibility pH/H2O2 dual sensitive stick...

Formulation workers use the characteristics of low pH , high H ₂ O ₂ and highly expressed specific receptors in the tumor microenvironment to construct a pH / H ₂ O ₂ sensitive and multifunctional nano-drug delivery targeting highly expressed tumor specific receptors.
The platform aims to effectively target the delivery of drugs to tumor tissues or cells to achieve targeted therapy of tumors
.

Chiral mesoporous silicon nanorods are mesoporous silicon inorganic materials .

Recently, the School of Pharmacy, Shenyang Pharmaceutical University, Professor LI San-ming Task Force and the Task Force Medical Chinese Li He ran in " ACS Applied Materials & Interfaces on the" journal published a report entitled " the pH of / H ₂ O ₂ Dual-Responsive Chiral Mesoporous Silica Coated with A Nanorods Biocompatible Active Targeting Ligand for Cancer Therapy " research paper
.

The drug delivery system constructed in this article is based on the rod-shaped mesoporous silicon nanoparticles whose surface is easy to be functionalized, and the phenylboronic acid pinacol ester is grafted onto the surface of the rod-shaped mesoporous silicon nanoparticles to give the mesoporous silicon nanorods the chirality and The sensitivity to H ₂ O ₂ can be prevented by loading the anticancer drug adriamycin into the pores of the nanoparticles, and then wrapping the hyaluronic acid - cyclodextrin copolymer on the surface of the particles as a " supramolecular switch " .
The premature release of doxorubicin can give the particles active targeting

Diagram 1.

( A ) The synthesis pathway of pH/H ₂ O ₂ dual-sensitivity HA-CD/DOX-PCMSRs ; ( B ) The internalization of HA-CD/DOX-PCMSRs and the particles in tumor cells mediated by the CD44 receptor The mechanism of drug release under the action of pH/H ₂ O ₂ dual stimulus factors .

Highlights of this article

Figure 1.

Characterization of

College of Pharmacy doctoral graduate Shenyang Pharmaceutical University, Wang Mei first author for the paper, research was supported by the National Natural Science Foundation of China ( No.

81,773,672 and No.
81.

Related Links

https://doi.
org/10.
1021/acsami.
1c08532