echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > ACS Nano, a top journal in the field of nanomedicine, published the research results of Shao Longquan's team

    ACS Nano, a top journal in the field of nanomedicine, published the research results of Shao Longquan's team

    • Last Update: 2022-10-31
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
      

    Recently, the Shao Longquan team of the Stomatological Hospital published a review article
    entitled "How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects" online in ACS Nano, a top journal in the field of nanomedicine.

    Biological barriers such as respiratory tract, digestive tract, skin, blood brain, placenta are important lines of defense to protect the human body from pathogenic microorganisms and harmful substances, but they also become the biggest obstacle to
    the absorption of hydrophilic macromolecular drugs.
    With the development of nanomedicine, the interaction between nanomaterials and biological barriers has attracted more and more attention
    .
    However, existing studies have focused on how nanomaterials cross biological barriers through the cell-penetrating pathway, and there is a lack of systematic review
    of how nanomaterials affect paracellular transport pathways, resulting in toxic or therapeutic effects on target organs.
    Based on this, this paper is the first to start from the perspective of nanomaterials opening the cell bypass pathway, and explain the interaction
    between nanomaterials and biological barriers.

    In this paper, the intrinsic molecular mechanism of nanomaterials affecting the structure and function of key proteins in cellular bypass pathways (mainly tight junctions, adhesion junctions and cytoskeletons) is first discussed, and the nanomaterials are systematically summarized to further regulate cell bypass pathways and open biological barriers
    by directly interacting with protein components on cell membranes, by affecting oxidative stress and inflammatory effects.
    Secondly, this paper summarizes the factors affecting the ability of nanomaterials to open cell bypass pathways, and proposes a design strategy
    for nanomaterials to improve the efficiency of paracellular transport more safely and effectively.
    Finally, based on the current status of mechanism research in related fields, the limitations of existing research models and methods and future research directions
    are proposed.
    Based on a series of analytical discussions on the interaction between NPs and gatekeepers regulating cellular bypass pathways and their molecular mechanisms, this review provides new insights
    for nanomaterials to cross various biological barriers to achieve safe, controllable and efficient drug delivery.

    Wu Junrong, a postdoctoral fellow at the Stomatological Hospital of Southern Medical University, is the first author of this paper, and Professor Shao Longquan is the corresponding author
    .
    Taking the biological effects of nanomaterials as the starting point, Professor Shao's research group conducted systematic and in-depth research on the related roles and internal mechanisms of nanomaterials in promoting tissue repair and regeneration, regulating nerve function, and antibacterial, and the research results were published in Adv Funct Mater, ACS Nano, Bioact Mater, Adv Drug Deliver Rev, J Hazard Mater, J Control Release, J Nanobiotechnol, Microbiol Spectr, J Dent Res and other international high-level journals
    .

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.