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    Home > ACS Nano: don't want to go on a diet, don't exercise, micro needle skin patch makes it possible to lie down and lose weight

    ACS Nano: don't want to go on a diet, don't exercise, micro needle skin patch makes it possible to lie down and lose weight

    • Last Update: 2017-10-10
    • Source: Internet
    • Author: User
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    According to research data from Imperial College of technology, there are nearly 650 million obese people in the world, and obesity has spread all over the world Although controlling diet and increasing exercise can help many obese people to return to normal weight, severe obese patients often need medical or surgical treatment Recently, scientists from North Carolina State University and Columbia University have invented a micro needle skin patch that can "lose weight while lying down" This skin patch can transform white adipose tissue into brown adipose tissue through slow-release drugs, which is often accompanied by an increase in overall metabolism, so it can burn more fat and treat obesity The patch was selectively applied to the fat deposition site In mouse experiments, the patch successfully eliminated the excess fat deposition This is considered to be a potential option for the treatment of obesity, type 2 diabetes and other metabolic disorders Electron micrograph of the microneedle patch (left) containing nanoparticles of fat transforming drugs (right) (source: C & EN) white and brown adipose tissue Two kinds of adipose tissue are the most common in human body white adipose tissue can store extra energy in the form of triglycerides in human body With the accumulation of fat layer, it accumulates in all parts of the body to form obesity Brown adipose tissue contains more mitochondria, which can decompose brown fat and produce energy faster than white fat Scientists have been trying to turn white fat into brown fat, which can easily burn off body fat This transformation occurs naturally when the body is exposed to low temperatures, but in other cases it is difficult This transformation of fat is considered to be one of the ways to treat diabetes and obesity There are already some drugs on the market, such as rosiglitazone, which can transform white adipose tissue into brown adipose tissue, so as to help obese people lose weight, but the side effects of these drugs are also obvious, so it is difficult to take or inject them directly Rosiglitazone (source: C&EN) is a new technology for the treatment of obesity The microneedles made from the hydrogel on weight loss patches developed by Zhen Gu and Li Qiang team from two Chinese scholars from the United States each have a diameter of only 300 microns In such a fine structure, nanoparticles are further implanted - they are about 250 nanometers in size, equivalent to 1 / 400 of human hair These nanoparticles contain rosiglitazone, a "browning" drug, and glucose oxidase and catalase, which assist in drug release In the presence of glucose, these two enzymes can effectively create an acidic microenvironment and promote the release of drugs Animal experiments in mice: on both sides of the lower abdomen of the same mouse, carry a patch with medicine, and a patch without medicine Patches are changed every three days for a total of four weeks The results showed that the fat deposition of the drug application site was reduced by 20% compared with the drug free side In addition, the blood sugar of the treated mice was lower than that of the untreated mice When the subjects were normal or lean mice, their oxygen consumption increased by 20% compared with the control group This is an indicator of the rise in metabolism After gene testing and analysis, the researchers found that the treated sites contained more genes related to brown fat than other sites Li Qiang, one of the team leaders, pointed out that compared with liposuction, micro needle skin patch can pierce the skin without pain This non-invasive and non-invasive method can not only reduce more fat, but also reduce the local and slow drug release to the minimum side effects These patches can be used not only for body beauty, but also for the treatment of metabolic diseases such as obesity and diabetes Next they will try to test them in humans and check their effectiveness and safety in clinical trials Paper link: http://pubs.acs.org/doi/abs/10.1021% 2fassno.7b0434 the Gu group: http://gulab.bme.unc.edu/
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