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    Home > ACS Omega: Chinese ink can effectively "kill" cancer cells

    ACS Omega: Chinese ink can effectively "kill" cancer cells

    • Last Update: 2017-09-28
    • Source: Internet
    • Author: User
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    Ink, for the Chinese people, will not be strange For hundreds of years, Chinese calligraphers have created numerous paintings and calligraphy works with plant ink Recently, the research team of Shanghai Cancer Research Institute of Fudan University found that the plant ink can effectively treat cancer cells that spread or metastasize to lymph nodes noninvasively Source: in fact, one of the main factors leading to the death of cancer patients is cancer metastasis - cancer cells leave the original tumor, wander in the body and attack some important organs The lymphatic system is an important defense system throughout the body, which is composed of lymph, lymphatic vessels and lymph nodes As cancer cells leave the tumor, they often move through lymph nodes to other parts of the body In this case, the main treatment is surgery, but it may lead to many complications Photothermal therapy (PTT) is a new non-invasive treatment scheme Nanomaterials are injected into cancer cells to accumulate in them By irradiating these cells with lasers, nanoparticles absorb heat to heat the cells and kill the cancer cells However, these nanomaterials are usually expensive, difficult to manufacture or toxic Surprisingly, a traditional Chinese ink called Hu ink has similar properties to the nanomaterials used in PTT In the X-ray diffraction (XRD) pattern, there is no other characteristic peak except the carbon peak, which confirms that the main component of hukaiwen ink is carbon Hu Kaiwen ink was stable when it was kept at room temperature for 3 days So the researchers want to explore whether Huhu Kaiwen ink can be a good substitute for nano materials used in PTT Researchers analyzed Hu ink and found that it consists of nanoparticles and thin carbon layers The Raman spectrum shows that there is a Raman D peak near 1350cm-1, and the intensity ratio of D peak to G peak is ID / Ig = 0.96, which confirms the existence of thin carbon layer in Hu mo The Raman spectrum of Hu ink (source: ACS omega) when Hu ink is heated by laser, its temperature rises 131 degrees Fahrenheit, far higher than the current nano materials Under the condition of PPT, Hu Kaiwen ink killed the cancer cells in the laboratory dish Under normal circumstances, ink is non-toxic Hu Kaiwen ink also killed cancer cells when it was used in mice tumor treatment experiments The concentration of Hu ink also affects the death rate of cancer cells As shown in the figure below: since there are no dead cancer cells, colon cancer cells (HCT-116) only emit green fluorescence in the control group of normal saline (NS) However, in the 25 μ g / ml Hu ink group, nearly 50% of the cells died through heat treatment, thus giving off red fluorescence In the 50 μ g / ml Hu ink group, almost all the colon cancer cells (HCT-116) died and all of them gave off red fluorescence Therefore, the PTT effect can be improved by increasing the concentration of Hu ink at tumor site without increasing the power of NIR laser The concentration of Hu ink affects the effect of PTT (source: ACS omega) The researchers also pointed out that Hu ink can also be used as a probe to locate tumors and metastases, because it can absorb near-infrared light through the skin In addition, the study found that even if the storage time of Hu ink was extended to 90 days, its photothermal effect was almost unchanged (Fig 3b), indicating that Hu ink had a stable photothermal effect Hu ink has good photothermal effect, high stability in clinical storage, and great potential in clinical application of PTT for cancer treatment This new technology may bring a broad prospect for cancer treatment Ink can cure cancer I have to admire the power of Chinese ink! Paper link: http://pubs.acs.org/doi/full/10.1021/acsomega.7b00993
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