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    Home > Active Ingredient News > Study of Nervous System > Acta Neuropathologica: Children's on-screen tube melanoma: not just RELA or YAP

    Acta Neuropathologica: Children's on-screen tube melanoma: not just RELA or YAP

    • Last Update: 2021-02-04
    • Source: Internet
    • Author: User
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    Cervial meningoma is the second most common malignant intracranial tumor in children and young people.
    in childhood, cerial meningoma occurs in all parts of the central nervous system (CNS), most commonly in the posterior cranial den, followed by the on-screen and spinal areas.
    based on histological similarities, different parts of the tracheal melanoma used to be considered a whole.
    potential genetic changes in ocystotylan muscomas were included in the WHO Brain Tumor Classification 2016.
    study, the on-screen tube melanoma and RELA fusion is a unique entity.
    has identified seven different RELA fusion variants, which account for about 70 percent of the cerial membrane tumors in children.
    addition to the room tube mesothelioma with RELA fusion, YAP1-MAMLD1 fused tumors are thought to be the second entity to appear in the children's curtain chamber.
    , the prognosis of YAP1-MAMLD1 fusion was good compared to that of RELA fusion tumors with poor prognosis.
    in this study, we reported 18 cases of non-RELA/non-YAP on-screen tracheal membrane tumors in children, which were systematically characterized through their histology, immunosomics, genetics, and epigenomics.
    comprehensive molecular analysis includes high-resolution copy number analysis, methylation analysis, fusion transcripts and RNA sequencing through Nanostring technology.
    based on histological and immunoglostification characteristics, two main types were identified in this study -- RELA-like chamber membrane tumor (9 cases) and stretch cell chamber membrane tumor (6 cases).
    in the RELA sample group that is histologically GRADE III and is similar to RELA-fused cerium membrane tumors, the tumor lacks the nuclear expression of p65-RelA as an alternative marker for pathological activation of the NF-terra-B pathology.
    three tumors showed selective fusion with C11orf95 of MAML2 or NCOA1.
    a methylated brain tumor classifier classified two RELA-like tumors as methylated "EP, RELA-fusion";
    in the stretch cell chamber membrane tumor group, 5/6 of the tumors were classified as WHOII.grade, and no gene fusion was detected, and methylation analysis did not show any association with the established methylation category.
    of this study, in addition to the cerberal meningiomas currently found, there are at least two types of on-screen cytomanomas (RELA and stretch cell types).
    this study recommends a comprehensive histopathological and genetic diagnosis of epidural membrane tumors in order to accurately identify and further identify these tumors.
    Zschernack, V., Jünger, S.T., Mynarek, M. et al. Supratentorial ependymoma in childhood: more than just RELA or YAP. Acta Neuropathol (2021). MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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