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Pineal parenchymal tumor is a rare central nervous system (CNS) tumor, including a series of entities with different histological manifestations and clinical phenotypes.
Recently, genomic studies have revealed the biology and heterogeneity of pineal parenchymal tumors, especially PBs and PPTIDs.
Figure 1: Overview of the clinical and molecular characteristics of pineal parenchymal tumors
This study defines four clinical and biologically relevant consensus PB groups, including PB-miRNA1 (n=96), PB-miRNA2 (n=23), PB-MYC/FOXR2 (n=34) and PB-RB1 (N=25).
consensus
The results of the study show that there are significant differences in the age at diagnosis , gender preference and metastasis status of different tumor groups .
diagnosis
In summary, this study confirmed the clinical and biological heterogeneity of pineal parenchymal tumors and proposed a consistent set of molecules.
management
Original source:
Original source:Liu, APY, Li, BK, Pfaff, E.
Liu, APY, Li, BK, Pfaff, E.
et al.
springer.
com/article/10.
1007/s00401-021-02284-5" target="_blank" rel="noopener"> Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
springer.
com/article/10.
1007/s00401-021-02284-5" target="_blank" rel="noopener">Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Acta Neuropathol 141, 771–785 (2021 ).
https://doi.
org/10.
1007/s00401-021-02284-5 Leave a message here
