echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Infection > Acta Neuropathologica: Prions are widely distributed in the peripheral tissues of patients with vCJD and sCJD

    Acta Neuropathologica: Prions are widely distributed in the peripheral tissues of patients with vCJD and sCJD

    • Last Update: 2021-03-21
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Infectious spongiform encephalopathy (TSEs), or prion diseases, is a fatal neurodegenerative disease.


    The transmission of prions is mainly the conversion of normal cell prion protein (PrP C ) into abnormal disease-related subtypes (PrP Sc ) in the brain and other tissues of infected individuals .


    In 1996, a new type of CJD was discovered in humans, called variant CJD (vCJD).


    prevention

    In sharp contrast to vCJD, previous studies of sCJD patients showed low or inconsistent levels of PrP Sc in peripheral tissues , or undetectable PrP Sc .


    Sc Sc consensus

    In this study, the researchers systematically measured the level of prion infection in the central nervous system and peripheral tissues collected from patients with vCJD and sCJD.


    For the non-lymphoid peripheral tissues studied, variable and lower infectious titers were detected in both sCJD and vCJD patients.


    In summary, in the peripheral tissues of patients infected with sCJD, there are still many uncertain factors in the early accumulation and infectivity of prions, and the risk of iatrogenic transmission related to peripheral tissues of sCJD cannot be ignored.


    In the peripheral tissues of patients infected with sCJD, there are still many uncertain factors in the early accumulation and infectivity of prions.


    Douet, JY.
    , Huor, A.
    , Cassard, H.
    et al.
    springer.
    com/article/10.
    1007/s00401-021-02270-x" target="_blank" rel="noopener">Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients.
    springer.
    com/article/10.
    1007/s00401-021-02270-x" target="_blank" rel="noopener"> Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients.
    Acta Neuropathol 141 ,  383–397 (2021).
    https://doi.
    org/10.
    1007/s00401-021-02270-x Leave a message here springer.
    com/article/10.
    1007/s00401-021-02270-x" target="_blank" rel="noopener"> springer.
    com/article/10.
    1007/s00401-021-02270-x" target="_blank" rel="noopener"> 
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.