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Infectious spongiform encephalopathy (TSEs), or prion diseases, is a fatal neurodegenerative disease.
The transmission of prions is mainly the conversion of normal cell prion protein (PrP C ) into abnormal disease-related subtypes (PrP Sc ) in the brain and other tissues of infected individuals .
In 1996, a new type of CJD was discovered in humans, called variant CJD (vCJD).
prevention
In sharp contrast to vCJD, previous studies of sCJD patients showed low or inconsistent levels of PrP Sc in peripheral tissues , or undetectable PrP Sc .
Sc Sc consensus
In this study, the researchers systematically measured the level of prion infection in the central nervous system and peripheral tissues collected from patients with vCJD and sCJD.
For the non-lymphoid peripheral tissues studied, variable and lower infectious titers were detected in both sCJD and vCJD patients.
In summary, in the peripheral tissues of patients infected with sCJD, there are still many uncertain factors in the early accumulation and infectivity of prions, and the risk of iatrogenic transmission related to peripheral tissues of sCJD cannot be ignored.
In the peripheral tissues of patients infected with sCJD, there are still many uncertain factors in the early accumulation and infectivity of prions.
Douet, JY.
, Huor, A.
, Cassard, H.
et al.
springer.
com/article/10.
1007/s00401-021-02270-x" target="_blank" rel="noopener">Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients.
springer.
com/article/10.
1007/s00401-021-02270-x" target="_blank" rel="noopener"> Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients.
Acta Neuropathol 141 , 383–397 (2021).
https://doi.
org/10.
1007/s00401-021-02270-x Leave a message here springer.
com/article/10.
1007/s00401-021-02270-x" target="_blank" rel="noopener"> springer.
com/article/10.
1007/s00401-021-02270-x" target="_blank" rel="noopener">