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Acta Neuropathologica: The heterogeneity of alpha-synuclein fibril activity in patients with Lewy body dementia is related to disease phenotype

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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The aggregation of alpha-synuclein is a typical pathology of synucleinopathies, including Parkinson's disease (PD), Lewy body dementia (DLB) and multiple system atrophy (MSA).

The aggregation of α-synuclein is a typical pathology of synucleinopathies, including Parkinson's disease (PD), Lewy body dementia (DLB) and multiple system atrophy (MSA).

Analysis aimed at identifying the conformation of template fibers present in tissues and biological fluids includes protein misfolding cyclic amplification (PMCA) and related real-time shock-induced transformation (RT-QuIC) methods.

Recent studies have highlighted the structural variation associated with α-synuclein aggregates in the patient population.

The α-synuclein fibril activity in the cerebral cortex extract of DLB patients is correlated with the CSF activity of the matched ventricle.

The results of this article emphasize the previously unknown wide heterogeneity of fiber template activity in DLB, which may be related to the disease phenotype.

The extensive heterogeneity of fiber template activity in DLB may be related to the disease phenotype.

Sokratian, A.
, Ziaee, J.
, Kelly, K.
et al.
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1007/s00401-021-02288-1" target="_blank" rel="noopener"> -synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
Acta Neuropathol 141, 547–564 (2021).
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