Additional markers in the diagnosis of rheumatoid arthritis

Recently, the team of Professor Zhang Xuan from Peking Union Medical College Hospital discovered two new types of rheumatoid arthritis markers, anti-PTX3 and anti-DUSP11, which help to identify patients with rheumatoid arthritis early.

Early diagnosis and treatment of rheumatoid arthritis is the key to preventing irreversible joint destruction.

Zhang Xuan’s team has been researching and searching for effective diagnostic markers for rheumatoid arthritis in the past 8 years, collected thousands of specimens, and reported for the first time in the world: anti-PTX3 and anti-DUSP11 autoantibodies can be used as diagnostic markers for ACPA-negative rheumatoid arthritis .

The research team found that the combined diagnosis of anti-PTX3 and anti-DUSP11 autoantibodies has good diagnostic sensitivity and specificity.

In order to understand the role of the new markers in the pathogenesis of rheumatoid arthritis, the team further studied and found that the PTX3 protein was significantly increased in the serum of patients with rheumatoid arthritis.

This series of results provides a theoretical basis and new ideas for the design of small molecule inhibitors for the treatment of rheumatoid arthritis.