echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Adenovirus causes fulminant hepatitis, fatality rate was as high as 70%

    Adenovirus causes fulminant hepatitis, fatality rate was as high as 70%

    • Last Update: 2022-05-11
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Adenovirus is a DNA virus that usually causes mild infections in humans , including upper or lower respiratory tract, gastrointestinal, and conjunctival infections


    Adenovirus is a DNA virus, adenovirus is a DNA virus that usually causes mild infections in humans , usually causes mild infections in humans, rare manifestations, rare manifestations

    As early as 2016, a study "Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention" has explained all diseases of adenovirus infection, including adenovirus-induced hepatitis , see Figure 1


    All diseases of adenovirus infection, including adenovirus-induced hepatitis All diseases of adenovirus infection, including adenovirus-induced hepatitis

    Figure 1: Global spread of adenoviruses and advances in treatment and prevention

    Figure 1: Global spread of adenoviruses and advances in treatment and prevention

    The study confirmed that adenovirus infection is more common in children due to lack of humoral immunity, which is also in line with the epidemiology of this unexplained hepatitis


    The study confirmed that adenovirus infection is more common in children due to lack of humoral immunity, which is also in line with the epidemiology of this unexplained hepatitis


    Respiratory infections are more common

    Respiratory infections are more common Respiratory infections are more common

    Adenoviruses account for at least 5% to 10% of respiratory infections in children and 1% to 7% of respiratory infections in adults


    Typical symptoms of adenovirus respiratory infection include fever, pharyngitis, tonsillitis, cough, and sore throat, and gastrointestinal symptoms may be present, especially in children


    Other diseases of adenovirus infection

    Other diseases of adenovirus infection Other diseases of adenovirus infection

    Adenovirus infection can cause gastrointestinal symptoms even when the primary site of involvement is the respiratory tract


    Adenovirus infection can cause gastrointestinal symptoms even when the primary site of involvement is the respiratory tract


    Figure 2: Pathological changes in patients with adenovirus hepatitis

    Figure 2: Pathological changes in patients with adenovirus hepatitis

    In addition, adenovirus-induced keratoconjunctivitis is also common , the most common serotypes are AdV-8, AdV-19 and AdV-37, other serotypes such as AdV-3, AdV-4, AdV-7, AdV- 11 and AdV-14, can also cause conjunctivitis


    Adenovirus-induced keratoconjunctivitis is also common Adenovirus-induced keratoconjunctivitis is also common

    Immune function and adenovirus infection

    Immune function and adenovirus infection Immune function and adenovirus infection

    The prevalence of adenovirus infection is overwhelmingly self-limiting ; disseminated and fatal infections are rare in immunocompetent hosts


    Self-limiting and self-limiting but in immunocompromised patients, the lesions caused by adenovirus infection can be more severe and even fatal


    Adenovirus infection may also complicate congenital immunodeficiency diseases , such as severe combined immunodeficiency syndrome, common variant immunodeficiency, agammaglobulinemia, and immunoglobulin A deficiency


    Adenovirus infection, which may also complicate congenital immunodeficiency disease

    Another study reported (see Figure 3) of adenoviral hepatitis that included 89 patients with adenoviral hepatitis cases


    Figure 3: Cover of the paper on the prevalence of human adenovirus hepatitis

    Figure 3: Cover of the paper on the prevalence of human adenovirus hepatitis

    90% of patients present within 6 months of transplantation


    Fever is the most common initial symptom Fever is the most common initial symptom

    Only 24 of the 89 patients (27%) survived: 16 with reduced immunosuppression, 6 with a repeat liver transplant, and 2 with cidofovir and intravenous immunoglobulin


    Coping and Treatment

    coping and treatment coping and treatment

    Since the World Health Organization (WHO) published "Acute Hepatitis of Unknown Cause in the United Kingdom" on April 15, 2022, cases of acute hepatitis of unknown cause in children have been reported worldwide


    According to the WHO assessment, it is unclear whether the number of new cases of unexplained hepatitis has increased since April or whether there has been a gradual increase in awareness of unexplained hepatitis cases
    .
    Although adenovirus is a possible etiology, investigations into causative factors are still ongoing
    .

    Adenoviral hepatitis can manifest as fulminant disease in immunocompromised hosts, the researchers said — "Definite diagnosis requires liver biopsy, early identification of viral subtypes, reduced immunosuppression, and liver transplantation may be life-saving
    .
    "

    "Definite diagnosis requires liver biopsy, and early identification of viral subtypes, reduced immunosuppression
    , and liver transplantation may save lives
    .
    "

    The treatment of unexplained hepatitis is currently mainly symptomatic.
    Antiviral drugs are used for viral infections.
    Once the liver cannot support the body, liver transplantation is used
    .

    For the treatment of unexplained hepatitis, the current treatment for unexplained hepatitis is mainly symptomatic.

    references:

    [1] Ronan BA, Agrwal N, Carey EJ, et al.
    Fulminant hepatitis due to human adenovirus.
    Infection.
    2014;42(1):105-111.
    doi:10.
    1007/s15010-013-0527-7.
    Epub 2013 Aug 24.
    PMID: 23979854.

    [2] Lynch JP 3rd, Kajon AE.
    Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.
    Semin Respir Crit Care Med.
    2016;37(4):586-602.
    doi: 10.
    1055/s- 0036-1584923.
    Epub 2016 Aug 3.
    PMID: 27486739; PMCID: PMC7171713.

    [3] Lynch JP 3rd, Kajon AE.
    Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment.
    Semin Respir Crit Care Med.
    2021;42(6):800-821.
    doi: 10.
    1055/s-0041- 1733802.
    Epub 2021 Dec 16.
    PMID: 34918322.



    leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.