Adenovirus vector vaccine has a new explanation for the cause of thrombosis

Previous research reports stated that antibodies induced by adenovirus vector vaccines developed by Johnson & Johnson and AstraZeneca separately can cause dangerous thrombosis, and the safety of the vaccine has therefore aroused widespread concern

Previous studies have found that patients may develop "vaccine-induced immune thrombotic thrombocytopenia" (VITT) after being vaccinated with the adenovirus vector new crown vaccine

To reveal this mystery, the scientists analyzed the serum of 5 VITT patients who had received a dose of AstraZeneca in the latest study.

Studies have found that the antibodies obtained from the serum of these patients will bind to the PF4 protein involved in coagulation, and the binding site is the same as the binding site of heparin and PF4, which indicates that the antibodies induced by heparin and the new crown vaccine cause blood in a similar manner Congealed

Isaac Naz, the lead author of the latest study and an associate professor at McMaster University School of Medicine, said: "Our work answers important questions about the link between antibodies and thrombosis, and will have an impact on the diagnosis and treatment of the new coronavirus.

Researchers also said that the binding of antibodies to PF4 may not be the whole cause of thrombosis, but understanding how thrombus formation can help improve the safety of vaccines