ADHD is a new risk factor for Alzheimer's disease?

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by persistent low concentration, impaired impulse control, and hyperactivity
.

Follow-up studies have shown that ADHD usually lasts into adulthood, affecting 3% of adults worldwide
.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of aging-related cognition and independent living ability.
It is the most common subtype of dementia
.

As the life expectancy of individuals increases, dementia has become an important public health problem
.

Yimaitong compiles and organizes, please do not reprint without authorization
.

Research Introduction To study the degree of association between ADHD and AD, other types of dementia, and neurodegenerative diseases
.

The researchers selected approximately 2.
1 million people born in Sweden between 1980 and 2001 for the study
.

Overall, 3.
2% of people in this cohort were diagnosed with ADHD
.

The researchers then used the National Register to connect these ADHD patients with more than 5 million biological relatives, including parents, grandparents, uncles, and aunts, and used the Cox model to determine which of these relatives would develop over time On dementia
.

 Main findings: ➤Parents of ADHD patients have a 34% higher risk of other types of dementia than parents of non-ADHD patients (HR: 1.
34; 95% CI: 1.
11-1.
63)
.

 ➤AD is the most common type of dementia.
Parents of ADHD patients have a 55% higher risk of AD (HR: 1.
55; 95% CI: 1.
26-1.
89)
.

 ➤Parents of ADHD patients are more likely to have early-onset dementia rather than late-onset dementia
.

However, the absolute risk of dementia in the parent cohort was low: only 0.
17% of parents were diagnosed with dementia during follow-up
.

 ➤The association between ADHD and dementia is not so strong for the second-degree relatives of ADHD patients
.

For example, grandparents of individuals with ADHD have a 10% increased risk of dementia compared with grandparents of individuals without ADHD
.

 Conclusion ADHD is associated with dementia between AD and other generations
.

This association weakens with the decrease of genetic correlation, which indicates that there is a common family risk between ADHD and AD
.

 Yimaitong compiled from: Zhang, Le, Rietz, EDu, Kuja-Halkola, R, et al.
Attention-deficit/hyperactivity disorder and Alzheimer's disease and any dementia: A multi-generation cohort study in Sweden.
Alzheimer's Dement.
2021; 1-9.
https://doi.
org/10.
1002/alz.
12462