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Obesity is a chronic disease that can lead to a variety of diseases, such as diabetes, cardiovascular disease, non-alcoholic fatty liver, tumors, etc.
Dietary weight loss method is currently a commonly used weight loss mode, such as caloric restriction diet (Caloric restriction, CR), in recent years the more popular is intermittent fasting (Intermittent fasting, IF), this method can be divided into day time limit diet, 1: 1 diet (eating day hunger one day), 5: 2 diet (eating five days, hungry two days) and so on
In September 2021, the Jin Wanzhu research team of the Institute of Zoology, Chinese Academy of Sciences published an article Hepatokine pregnancy zone protein governs the diet-induced thermogenesis through activating brown adipose tissue (DIO: 10.
PZP is a liver-specific highly secreted protein, which belongs to the α2M family of proteins
Kim Wan-soo’s team found that under normal high-fat diet conditions, PZP loss did not affect the weight of mice; while under the conditions of high-fat diet combined with intermittent light fasting, PZP loss caused a significant increase in the weight of mice
Brown fat is a special adipose tissue that produces heat and consumes energy.
In order to further analyze the molecular mechanism of PZP regulating energy metabolism, the team co-expressed the BAT cDNA library and PZP protein in cells, combined with immunoprecipitation and protein profiling techniques, and identified the GRP78 protein in BAT as the receptor for PZP
Under intermittent light fasting conditions, administration of exogenous PZP protein can reduce the weight gain of wild-type mice, but has no effect on the weight of UCP1-deficient mice, indicating that the regulation of metabolism by PZP protein depends on UCP1 protein, and it also suggests In a certain metabolic state, supplementation of exogenous PZP protein has the effect of reducing obesity
The study clarified that under dietary induction, the PZP protein secreted by the liver can bind to the GRP78 receptor on brown adipose tissue, activate the p38 MAPK-ATF2-UCP1 signaling pathway to promote brown fat thermogenesis, improve obesity and related metabolic disorders, revealing The molecular mechanism of the interaction between the liver and brown fat under intermittent diet conditions provides an important basis for the prevention and treatment of obesity by regulating thermogenesis.
Researcher Jin Wanzhu from the Institute of Zoology, Chinese Academy of Sciences and Chief Physician Zhang Chaoyun of the Endocrinology Department of Huashan Hospital Affiliated to Fudan University are the co-corresponding authors of this study
Article link: https://onlinelibrary.