Advances have been made in the study of the mechanism of gene expression regulation in the general wheat TagS2 genome.

Common wheat is one of the world's most important food crops, containing A, B and D genomes, different genomes of the same gene in the process of multiply functional differentiation or redundancy.
analysis of genomic quasogene gene expression regulation mechanism is helpful to deepen the understanding of functional genes and lay a theoretical foundation for the design and cultivation of new wheat varieties.
Junming research group of the Agricultural Resources Research Center of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has made new progress in the regulation of the expression of homogenous genes in the hexaplogeneous wheat genome in osceogenetics and chromatin structures.
the study used Konon 9204 wheat missing mutants to demonstrate that the genomic congener gene (TaGS2-A, TaGS2-B, and TaGS2-D), a key gene in the nitrogen metabolism process, was functionally redundant.
TaGS2 expression has obvious space-time specificity, mainly in the early leaves of the ground, where the TaGS2-B expression is significantly higher than TaGS2-A and TaGS2-D, while the root expression is inhibited.
ChIP and BSP results show that TaGS2 space-time expression specificity and genomic omogene gene expression differences are jointly regulated by higlobin H3K4m3 and DNA cytosine methylation.
of chromatin structure show that the distribution of nucleosomes in the initiator region is mainly involved in the regulation of space-time expression of TaGS2.
, the distribution of nucleosomes in the transcriptional region was mainly involved in fine-tuning the differences in the expression of the Same gene in the TaGS2 genome.
results show that histogeneic modification, DNA methylation, and nucleosome distribution co-regulate the expression of the key gene of nitrogen metabolism, TagS2.
the results were published in the journal Scientific Reports (DOI:10.1038/srep44677), and were co-authors Zhang Wei, associate researcher of Li Junming's research team, Dr. Yu Xiaoli of the Chengdu Institute of Biology of the Chinese Academy of Sciences, and Gao Yingjie of Hebei Normal University.
research has been funded by the National Natural Science Foundation of China, the National Key Research and Development Program and other projects.
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