Advances in the analysis and evolution of plant NAD remediation synthesis pathways.

NAD (Nickamide adenine dinucleotides) is well known to researchers as an electron delivery vector (coenzyme) involved in numerous oxidation responses.
In the Plant NAD Remediation Synthesis Pathway (Preiss-Handler Pathway), specific nicotinate (NA) and various NA derivatives (glycosylation, methylation, etc.) are present, but so far no molecular mechanisms and physiological functions of NA derivatives in plant metabolism have been reported.
Early research by the Wang Dong Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences suggests that NA's O-bit glycosylation modification may protect plant cells from the poison caused by NA's excessive accumulation during seed germination, and that NAOGT activity is gradually obtained during the evolution of crustal plants, and that the gain of NAOGT activity provides a selective advantage for plant adaptation (Li et al., Plant, 2015).
Recently, the Wangdong Research Group found that a new class of N-methyl transferase (NANMT, At3g53140 encoding) is responsible for the production of Nick acid N-methylated compounds (a.k.a. hulubarb), while Nickic acid N-methylation modification is another form of plant detoxIFICATION NA.
comprehensive evolutionary and biochemical analysis results show that the function of this new type of nicotic acid N-methyl transferase comes from the replication and functional differentiation of THET (coffee acid O-methyl transferase) genes involved in plant ligand biosynthesis pathways.
plant-based COMT also retains weak NANMT activity, indicating that the gain of NANMT activity during the long evolution of plants contributed to the retention of the Preiss-Handler pathway in the land plant genome.
the study was published online May 22 at Plant Physiology (DOI: 10.1104/pp.17.00259).
Wei, Zhang Fengxia and Wu Ranran of the Wang Dong Research Group in The Kingdom of China, are the co-authors of this article.
project was funded by the National Natural Science Foundation of China, the Ministry of Science and Technology's "973" project and the National Key Laboratory of Plant Genomics.
.