Advances in the study of targeted regulatory mechanisms of epigenetic modification.

Epigenetic regulation is one of the important mechanisms of organism regulation gene expression and chromosomal behavior, and it plays an important role in gene expression regulation, transposon silence, genomic stability and biological growth and development.
in plants, epigenetic regulation is widespread, and in plantresponse to the outside environment, control growth and development plasticity and other aspects play an important role.
With the development of high-throughput sequencing technology in recent years, epigenome regulatory spectra are gradually displayed in front of people.
the precise regulation of epigenetic factors to the target site is very important to the function of the target site, however, people's understanding of how epigenetic factors can accurately locate target sites in the whole genome range is still very limited. Cao Xiaofeng Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences,
, has long been devoted to the study of the genetic regulatory mechanism of higher plant epigenetics, revealing that the amoeba mustard protein demethylatase JMJ14 (Cell Discov, 2015) and REF6/JMJ12 (Nat Genet, 2011, 2016) are on chromat The positioning mechanism explains the molecular mechanism of the rice histone methyl transferase SDG714 (Plant Cell, 2007) and histone demethylase JMJ703 (PNAS, 2013) to regulate gene expression and maintain transposon activity, and reveals the important regulatory mechanism of histone modification factor to plant growth and development.
Cao Xiaofeng was recently invited to write a summary article entitled The Seekers: How epigenetic modifying enzymes find their hidden targets in Arabidopsis (DOI: 10.1016/j.pbi 2018.05.006), a systematic summary of how epigenetic factors in higher plants accurately identify the molecular mechanism of specific target genes in the genome, and its importance in the establishment of epigenome map is discussed in depth, and the future development direction and trend are put forward. Deng Xian, an associate researcher in the
Cao Xiaofeng Research Group, is the first author of the paper and Cao Xiaofeng is the author of the communication.
the work was funded by the National Natural Science Foundation of China, the Chinese Academy of Sciences' leading scientific research projects, and the Chinese Academy of Sciences Youth Promotion Association.
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