Aging Cell: Scientists Reveal Perredoxin 3 Can Clear Mitochondrial Hydrogen Peroxide To Treat Muscle Atrophy

The progressive loss of muscle mass and strength with age, known as sarcopenia, results in limited ability to perform daily activities in older adults, affecting quality of life and healthy longevity

Image credit: https://doi.

Recently, researchers from the Oklahoma Medical Research Foundation published a paper entitled "Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia" in the journal "Aging Cell".

First, the aim of this study was to determine the effect of mitochondrial hydrogen peroxide on neurogenic atrophy and contractile dysfunction

The researchers found that the basal production rate of H2O2 was increased in muscle mitochondria isolated from Sod1-knockout mice, which was normalized by mPRDX3 overexpression

Peroxiredoxin 3 Human Transgene Construction Map (PRDX3)

Image credit: https://doi.

Taken together, our data suggest that increased PRDX3 expression in skeletal muscle normalizes excess mitochondrial hydrogen peroxide production in redox-dependent sarcopenia

The present study also reports the novel finding that mPRDX3 overexpression improves muscle quantity and quality, although in redox-dependent sarcopenia, the effect of mPRDX3 on NMJ injury is insufficient

references

Bumsoo Ahn et al.