Aging Cell: Vitamin D receptor activation may increase the risk of Alzheimer's disease

With the aging of the world's population, the incidence of dementia is getting higher and higher
.

Alzheimer's disease (AD) accounts for 60%-80% of all cases of dementia, but there is currently no therapy that can prevent or slow the progression of this disease

Prevent vitamin D

However, vitamin D is not a vitamin, but a steroid hormone
.

Like other steroid hormones, vitamin D may trigger genomic and non-genomic cellular responses

The genomic action of vitamin D is initiated by binding to the vitamin D receptor (VDR) The genomic action of vitamin D is initiated by binding to the vitamin D receptor (VDR)

At present, there is already a lot of evidence that vitamin D plays a genomic role in the brain, and VDR has been found to be widely expressed in the main brain cell types that mediate brain development and function
.

At the same time, vitamin D also plays a non-genomic role in the brain
.

The non-genomic role of VDR is a rapid plasma membrane response to cell stimulation, but it does not seem to require VDR-RXR interaction

The non-genomic role of VDR is a rapid plasma membrane response to cell stimulation, but it does not seem to require VDR-RXR interaction

Although vitamin D decreased in AD patients and mice, hippocampal VDR levels increased in turn.

Aβ42 destroys the VDR/RXR complex of the genome and induces the formation of the VDR/p53 non-genomic complex
.

Aβ42 destroys the VDR/RXR complex of the genome and induces the formation of the VDR/p53 non-genomic complex
.

Aβ42 destroys the VDR/RXR complex of the genome and induces the formation of the VDR/p53 non-genomic complex

Aβ up-regulated VDR without its typical ligand vitamin D, and changed its isomer binding partner from RXR to p53.

 

Original source:

Original source:

Rai-Hua Lai et al.

Rai-Hua Lai et al.

 

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