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    Home > Active Ingredient News > Study of Nervous System > Aging Cell︱Xiao Jianhui's team reports a potential anti-aging drug: Ganoderma lucidate D activates the CaM/CaMKII/NRF2 signaling axis to delay stem cell aging

    Aging Cell︱Xiao Jianhui's team reports a potential anti-aging drug: Ganoderma lucidate D activates the CaM/CaMKII/NRF2 signaling axis to delay stem cell aging

    • Last Update: 2022-10-06
    • Source: Internet
    • Author: User
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    Source︱Sister of "Logical Neuroscience" "Lanhan Life Science"

    Written by Yuan Huan

    Editor in charge ︱ Wang Sizhen, Fang Yiyi

    Edited by Fang Yiyi

    Aging is the inevitable law of the life process and the source of all diseases

    On August 5, 2022, the team of Professor Jianhui Xiao from the Affiliated Hospital of Zunyi Medical University published a paper entitled "Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway on Aging Cell.


    In China, Ganoderma lucidum has a long history of edible and medicinal use as a valuable traditional Chinese medicine for anti-aging and treating aging-related diseases


    Figure 1 GA-D targeted binding to 14-3-3ε isoform

    (Source: Yuan, et al.

    In terms of mechanism studies, this study revealed that GA-D exerts anti-aging effects by targeting 14-3-3ε to regulate intracellular Ca 2+ and ROS levels, and analyzed CaM and its downstream signaling molecules CaMKII and phosphorylated CaMK (p -CaMKII) expression levels


    Figure 2 GA-D activates the CaM/CaMKII/NRF2 signaling axis to delay the senescence of hAMSCs

    (Source: Yuan, et al.

    At the overall level, the authors established a D-galactose (D-gal) aging mouse model to explore the anti-aging effects of GA-D


    Figure 3 The effect of GA-D on BMSCs of D-gal-induced aging mice

    (Source: Yuan, et al.


    Figure 4 Schematic diagram of the mechanism of GA-D delaying the senescence of hAMSCs

    (Source: Yuan, et al.

    Conclusion and discussion, inspiration and prospect.
    In conclusion, this study targeted stem cells, found that Ganoderma D (GA-D) has a significant anti-stem cell aging effect, and revealed that GA-D can target 14-3-3ε by targeting 14-3-3ε.
    The mechanism of activation of CaM/CaMKII and Nrf2/HO-1/NQO1 signaling pathway to exert anti-aging effect (Fig.

    GA-D exhibited consistent anti-aging effects in vivo, especially blocking D-gal-induced senescence of BMSCs in aging mice through the same protective mechanism as in vitro, suggesting that stem cell senescence models may be an effective anti-aging drug initially.
    The sieve model provides a new strategy for discovering anti-aging drugs; this research provides a scientific basis for the stem cell theory of aging

    In addition, this study revealed the material basis of the anti-aging effect of Ganoderma lucidum, and GA-D may be a potential anti-aging drug candidate, providing a scientific basis for the research and development of anti-aging Ganoderma lucidum-derived small molecule drugs

    At the same time, related research based on the stem cell aging model will help to reveal the regulatory network of aging-related molecular signals, and explore the targets and signaling pathways that interfere with aging, as well as potential anti-aging drugs

    However, the expression changes of the 14-3-3ε isoform suggest that the anti-aging mechanism of GA-D may involve other targets and molecular signaling regulation

    Original link: https://doi.

    About the corresponding author (swipe up and down to read) 

    Xiao Jianhui, Ph.
    , second-level professor, doctoral supervisor, enjoys special government allowances from the State Council, and is a core expert in Guizhou Province

    He is currently working at the Institute of Pharmaceutical Biotechnology, Affiliated Hospital of Zunyi Medical University

    Mainly engaged in basic and applied research in the field of microbial medicine and stem cells

    Published more than 100 papers in mainstream academic journals at home and abroad, and applied for nearly 30 national invention patents, of which 13 were authorized and 3 were transferred.
    Some research results won the first prize and second prize of the Guizhou Provincial Science and Technology Progress Award.
    , 1 first prize of the Natural Science Award of the Ministry of Education

    He has been successively selected into national, provincial and ministerial-level major talent projects such as the National "Ten Thousand Talents Program" Leading Talents in Science and Technology Innovation, the Ministry of Education's New Century Excellent Talents, and Guizhou Province's High-level Innovative Talents (Ten and Hundred-level)

    He is currently an associate editor of Biotechnology and Applied Biochemistry, an important academic journal of the International Union of Biochemistry and Molecular Biology (IUBMB) published by Wiley, and an editorial board member of several international academic journals

    Selected past articles

    【1】Mol Psychiatry︱Zheng Wei/Liao Fang team work together to reveal early events of white matter lesions in vascular cognitive impairment and dementia

    [2] Cell Rep | Xing Dajun's research group published a paper revealing the differences between the primary visual cortex of macaques and convolutional neural networks in integrating visuospatial information

    【3】Neuron|Hu Yang's group revealed a large number of genes that promote optic nerve regeneration and their significant neuroprotective effects in glaucoma mice

    【4】Cereb Cortex︱Zhang Yuxuan's research group reveals the neurophysiological evidence of task modulation in speech processing

    [5] Trends Cogn Sci︱Jiang Qiu team writes opinion articles on creative problem solving in knowledge-rich fields

    [6] Front Aging Neurosci︱ Hongmei Yu's team constructed a hierarchical multi-classification diagnosis framework for AD based on imaging features and clinical information

    【7】J Neurosci︱Jin Mingyue/Guangchang Shinji's team revealed that α-Syn and tau play an important synergistic physiological function during brain development

    【8】Cell Death Differ︱Xia Xiaobo's team revealed for the first time the relationship between "iron death" and the pathogenesis of glaucoma

    【9】Sci Adv︱ Zeng Kewu/Tu Pengfei’s team revealed a new target for the regulation of neuroinflammation by active ingredients of traditional Chinese medicine Yemazhui

    【10】JNE︱High-resolution time-frequency analysis estimates brain functional connectivity in EEG to help diagnose Alzheimer's disease

    Recommended high-quality scientific research training courses

    [1] Symposium on Single-Cell Sequencing and Spatial Transcriptomics Data Analysis (August 27-28, Tencent Online Conference)

    【2】Training course︱R language clinical prediction biomedical statistics special training

    [3] Workshop on Metagenomics and Metabolomics R Language Analysis and Visualization (Tencent Conference on August 27)

    Forum/Seminar Preview

    【1】Forum Preview︱Brain·Machine Intelligence Fusion——Let the brain connect to the future, the brain science theme forum is the first time!

    Welcome to "Logical Neuroscience" [1] Talent Recruitment︱"Logical Neuroscience" is looking for article interpretation/writing positions (part-time online, online office)

    References (swipe up and down to read) 

    [1] Boyette, LB, & Tuan, RS (2014).
    Adult stem cells and diseases of aging.
    Journal of Clinical Medicine, 3(1), 88–134.

    [2] Cianflone, E.
    , Torella, M.
    , Biamonte, F.
    , Angelis, AD, Urbanek, K.
    , Costanzo, FS, Rota, M.
    , Ellison-Hughes, GM, & Torella, D.
    (2020) .
    Targeting cardiac stem cell senescence to treat cardiac aging and disease.
    Cell, 9(6), 1558.

    [3] Díaz-Morenoa, M.
    , Armenterosb, T.
    , Gradaric, S.
    , Hortigüelaa, R.
    , GarcíaCorzob, L.
    , Fontán-Lozanoc, A.
    , Trejoc, J.
    , & Miraa, H.
    Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology.
    Proceedings of the National Academy of Sciences, 115(45), 11625–11630.

    [4] Tian, X.
    , & Li, Y.
    Endothelial cell senescence and age-related vascular diseases.
    Journal of Genetics and Genomics, 41(9), 485–495, 495.

    [5] Xu, Y.
    , Yuan, H.
    , Luo, Y.
    , Zhao, YJ, & Xiao, JH (2020).
    Ganoderic acid D protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK/NRF2 signaling pathway.
    Oxidative Medicine Cellular Longevity, 2020, 8291413.

    [6] Vyver, MVD, Powrie, YSL, & Smith, C.
    Targeting stem cells in chronic inflammatory diseases.
    Advances in Experimental Medicine and Biology, 1286(2021), 163–181.

    End of this article

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