Source︱Sister of "Logical Neuroscience" "Lanhan Life Science"
Written by Yuan Huan
Editor in charge ︱ Wang Sizhen, Fang Yiyi
Edited by Fang Yiyi
Aging is the inevitable law of the life process and the source of all diseases
On August 5, 2022, the team of Professor Jianhui Xiao from the Affiliated Hospital of Zunyi Medical University published a paper entitled "Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway on Aging Cell.
In China, Ganoderma lucidum has a long history of edible and medicinal use as a valuable traditional Chinese medicine for anti-aging and treating aging-related diseases
Figure 1 GA-D targeted binding to 14-3-3ε isoform
(Source: Yuan, et al.
In terms of mechanism studies, this study revealed that GA-D exerts anti-aging effects by targeting 14-3-3ε to regulate intracellular Ca 2+ and ROS levels, and analyzed CaM and its downstream signaling molecules CaMKII and phosphorylated CaMK (p -CaMKII) expression levels
Figure 2 GA-D activates the CaM/CaMKII/NRF2 signaling axis to delay the senescence of hAMSCs
(Source: Yuan, et al.
At the overall level, the authors established a D-galactose (D-gal) aging mouse model to explore the anti-aging effects of GA-D
Figure 3 The effect of GA-D on BMSCs of D-gal-induced aging mice
(Source: Yuan, et al.
Figure 4 Schematic diagram of the mechanism of GA-D delaying the senescence of hAMSCs
(Source: Yuan, et al.
Conclusion and discussion, inspiration and prospect.
In conclusion, this study targeted stem cells, found that Ganoderma D (GA-D) has a significant anti-stem cell aging effect, and revealed that GA-D can target 14-3-3ε by targeting 14-3-3ε.
The mechanism of activation of CaM/CaMKII and Nrf2/HO-1/NQO1 signaling pathway to exert anti-aging effect (Fig.
GA-D exhibited consistent anti-aging effects in vivo, especially blocking D-gal-induced senescence of BMSCs in aging mice through the same protective mechanism as in vitro, suggesting that stem cell senescence models may be an effective anti-aging drug initially.
The sieve model provides a new strategy for discovering anti-aging drugs; this research provides a scientific basis for the stem cell theory of aging
In addition, this study revealed the material basis of the anti-aging effect of Ganoderma lucidum, and GA-D may be a potential anti-aging drug candidate, providing a scientific basis for the research and development of anti-aging Ganoderma lucidum-derived small molecule drugs
At the same time, related research based on the stem cell aging model will help to reveal the regulatory network of aging-related molecular signals, and explore the targets and signaling pathways that interfere with aging, as well as potential anti-aging drugs
However, the expression changes of the 14-3-3ε isoform suggest that the anti-aging mechanism of GA-D may involve other targets and molecular signaling regulation
Original link: https://doi.
About the corresponding author (swipe up and down to read)
Xiao Jianhui, Ph.
, second-level professor, doctoral supervisor, enjoys special government allowances from the State Council, and is a core expert in Guizhou Province
He is currently working at the Institute of Pharmaceutical Biotechnology, Affiliated Hospital of Zunyi Medical University
Mainly engaged in basic and applied research in the field of microbial medicine and stem cells
Published more than 100 papers in mainstream academic journals at home and abroad, and applied for nearly 30 national invention patents, of which 13 were authorized and 3 were transferred.
Some research results won the first prize and second prize of the Guizhou Provincial Science and Technology Progress Award.
, 1 first prize of the Natural Science Award of the Ministry of Education
He has been successively selected into national, provincial and ministerial-level major talent projects such as the National "Ten Thousand Talents Program" Leading Talents in Science and Technology Innovation, the Ministry of Education's New Century Excellent Talents, and Guizhou Province's High-level Innovative Talents (Ten and Hundred-level)
He is currently an associate editor of Biotechnology and Applied Biochemistry, an important academic journal of the International Union of Biochemistry and Molecular Biology (IUBMB) published by Wiley, and an editorial board member of several international academic journals
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【3】Neuron｜Hu Yang's group revealed a large number of genes that promote optic nerve regeneration and their significant neuroprotective effects in glaucoma mice
【4】Cereb Cortex︱Zhang Yuxuan's research group reveals the neurophysiological evidence of task modulation in speech processing
 Trends Cogn Sci︱Jiang Qiu team writes opinion articles on creative problem solving in knowledge-rich fields
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【7】J Neurosci︱Jin Mingyue/Guangchang Shinji's team revealed that α-Syn and tau play an important synergistic physiological function during brain development
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【9】Sci Adv︱ Zeng Kewu/Tu Pengfei’s team revealed a new target for the regulation of neuroinflammation by active ingredients of traditional Chinese medicine Yemazhui
【10】JNE︱High-resolution time-frequency analysis estimates brain functional connectivity in EEG to help diagnose Alzheimer's diseaseRecommended high-quality scientific research training courses
 Symposium on Single-Cell Sequencing and Spatial Transcriptomics Data Analysis (August 27-28, Tencent Online Conference)
【2】Training course︱R language clinical prediction biomedical statistics special training
 Workshop on Metagenomics and Metabolomics R Language Analysis and Visualization (Tencent Conference on August 27)Forum/Seminar Preview
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