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    Home > Biochemistry News > Biotechnology News > Aging: it's more complicated than we thought

    Aging: it's more complicated than we thought

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    These nematodes are exposed to mitochondrial pressure, which induces the misfolding of proteins in their mitochondria, thereby activating the GFP report in the entire nematode



    Every cell in the human body undergoes thousands of chemical reactions every day, and each reaction involves the folding of tiny protein molecules into precise shapes to perform their functions


    Another major focus of aging research is mitochondria.


    An important new study in the Lithgow laboratory reveals an amazing discovery of the connection between protein shape and mitochondria, providing evidence for another subject in aging research: it is always much more complicated than we thought


    Mitochondria are jelly-shaped organelles that contain two membranes that allow them to maintain their own microenvironment


    Dr.


    Treatment of nematodes with cyclosporin A (a pharmacological method that keeps pores closed) can also prevent UPR mt from starting and restore their average lifespan


    Research on Caenorhabditis elegans is the basis of many aging studies, but what does this mean for efforts to promote health and prevent human diseases? Although the mitochondrial permeability transition pore has been associated with conditions such as stroke and heart attack, UPR mt The role of this is unclear


    This study found for the first time the connection between the "bad" process of pore opening and the "good" process of UPR mt


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    DOI

    10.


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