Aie research center of Shenzhen University: simple construction of red / near infrared AIE material and its application in diagnosis and treatment

In 2001, academician Tang benzhong of Hong Kong University of science and technology first proposed the new concept of "aggregation induced luminescence (AIE)", which led to the revolution of luminescent materials and became one of the frontier fields of chemistry and materials Red / Near-infrared Luminescent AIE materials have broad application prospects in biological imaging and treatment However, the complex preparation and purification process greatly hindered the practical application of such materials Aie research center of Shenzhen University has developed a variety of very simple synthesis strategies to prepare red / Near-infrared Luminescent Materials with AIE characteristics The prepared materials have simple structure, good solubility, large Stokes displacement and high luminous efficiency in the aggregation state They can specifically target lipid droplets (chem SCI 2019, DOI: 10.1039/c8sc05805a; adv funct Mater 2017, 1704039), cell membranes (chem SCI 2018, 9, 3685), mitochondria (adv mater 2018, 1802105), lysosomes and other organelles and bacteria, and show excellent light stability, high brightness and low working concentration, making them much better than the corresponding materials on the market (theranostics 2018, 8, 4925) In addition, they also have the ability of living oxygen or high efficiency of photothermal conversion, which makes them show excellent properties in photodynamic therapy, photothermal therapy, sterilization and other applications (angel chem Int ed 2019, DOI: 10.1002/anie.201900366) Aie research center of Shenzhen University was officially established in April 2018 The research center is affiliated to the school of materials, Shenzhen University Academician Tang benzhong, the father of AIE, is the honorary director of the research center, and Associate Professor Wang Dong is the director (Executive) The research center now has 3 full-time teachers, 3 part-time teachers, 14 postdoctoral and graduate students The research center mainly focuses on the preparation and application of AIE biomaterials with diagnostic and therapeutic functions, the development and application of room temperature phosphorescence (RTP) materials, AIE self-assembly materials, organic and inorganic AIE nanoclusters, and AIE polymer functional materials Introduction to academician Tang benzhong, academician of the Chinese Academy of Sciences, Professor Zhang Jianquan of science and technology of Hong Kong, Chair Professor of Department of chemistry and biomedical engineering, academician of Royal Society of chemistry, honorary director of AIE research center of Shenzhen University At present, he is the chief scientist of the 973 Program of the Ministry of science and technology, the project director of the basic science research center of NSFC, the leader of the introduction and innovation research team of Guangdong Province, and the editor in chief of materials chemistry frontiers, a joint Journal of the Chinese Chemical Society and the Royal chemical society Professor Tang benzhong has published more than 1000 academic papers, cited more than 60000 times, with an H index of 128 He was successively selected as a high cited scientist in the fields of chemistry and materials in 2014-2017 He has won a number of honors and awards, including the second National Natural Science Award, Croucher foundation Senior Researcher Award, Wang Baoren award of China Chemical Society, Feng Xinde award of Elsevier magazine, he Liang and he Li Foundation Science and technology progress award, 2017 China National Natural Science first prize, etc Wang Dong, Ph.D., associate professor, executive director of AIE Research Center, Shenzhen University The main research direction is the development of AIE materials, mechanism research, and application in chemical sensors, photoelectric devices, biological imaging and treatment So far, nearly 40 SCI papers have been published, among which more than 20 SCI papers have been published in the journals of chem Rev., chem SOC Rev., acc chem Res., angewchem Int ed., adv mater., adv funct Mater., theranomics, chem SCI Etc as the first author / correspondent One paper was selected as "ESI hot papers", two papers as "ESI high cited papers", and three papers as highlights were reported by synacts The paper has been cited more than 2000 times, h index 19 Cutting edge scientific research achievements: the simple construction of red / near infrared AIE materials and its application in diagnosis and treatment I The Application of AIE materials in photoacoustic induced photodynamic photothermal cancer treatment This work is the reverse thinking of the concept of AIE It mainly describes how to effectively use the energy dissipated by the non radiation decay pathway of AIE materials A series of AIE molecules with twisted structure, many rotors and strong absorption in the near infrared region have been prepared by a simple synthesis method Molecular dynamic simulation shows that one of the molecules (named TFM) exists in the form of amorphous state in the solid state, and the arrangement of molecules is disordered These characteristics greatly promote the efficient rotation of molecules in the aggregation state, and greatly improve the efficiency of excited state energy dissipation through the non radiation decay path The experimental results show that TFM nanoparticles have high photothermal conversion efficiency, good photoacoustic effect and the ability of producing active oxygen It was found that TFM nanoparticles can concentrate in the subcutaneous tumor site of mice with high specificity, and under the laser irradiation, TFM nanoparticles can effectively inhibit the growth of tumor in mice until the tumor is basically eliminated This study not only provides a new idea for the application of aggregation induced luminescence materials in the field of biology, but also provides a good template for the preparation of a new generation of integrated materials for diagnosis and treatment The application of TFM nanoparticles in photoacoustic induced photodynamic photothermal cancer therapy (source: Angel chem Int ed.) was recently published in Angel chem Int ed (DOI: 10.1002 / anie 201900366) The authors of this paper are: Dong Wang, * Michelle M S Lee, Wenhan Xu, guogang Shan, xiaoyanzheng, Ryan T K Kwok, Jacky W y Lam, Xianglong Hu, Ben Zhong Tang * 2 The application of high efficiency AIE photosensitive materials in cancer diagnosis and treatment Photodynamic therapy induced by fluorescence is an effective way to achieve the integration of cancer diagnosis and treatment At present, it is a great challenge to prepare materials with excellent properties such as high luminous efficiency, long emission wave, high efficiency of producing reactive oxygen species and good targeting to cancer cells In this work, a new class of far red / near infrared luminescent molecules with AIE properties have been synthesized These materials have many advantages, such as simple synthesis steps, good light stability, high luminous efficiency in aggregation state, large Stokes displacement, good biocompatibility and so on At the same time, their efficiency of producing living oxygen is as high as 90.7%, which is a potential excellent photosensitizer for photodynamic therapy It is found that without the use of additional targeting materials, these materials can specifically target cancer cells, but the staining effect on normal cells is not obvious Moreover, under the low power white light irradiation, these materials have a good inhibitory effect on the growth of subcutaneous tumor in mice High efficiency AIE photosensitive material has a good inhibitory effect on the growth of subcutaneous tumor in mice (source: adv mater.) this achievement was recently published in adv mater (adv mater 2018, 1802105) The authors of this paper are: Dong Wang, * Michelle M S Lee, guogang Shan, Ryan T K Kwok, Jacky W.Y Lam, Huang Su, Yuchen Cai, Ben Zhong Tang * The above research work was supported by NSFC and Shenzhen University Nowadays, people and scientific research have been paid more and more attention in the economic life China has ushered in the "node of science and technology explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeangoapp, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.