AJG: Changes in patients' total cholesterol levels and colorectal cancer risk after long-term use of statins

For decades, lipid-lowering statin drug is for the treatment of high cholesterol hyperlipidemia and reduce cardiac mortality and effects of drugs
.

At the same time, as a potential chemopreventive agent, statins have been studied in depth in the academic world, especially the impact on colorectal cancer (CRC) is a research hotspot

For decades, lipid-lowering statin drug is for the treatment of high cholesterol hyperlipidemia and reduce cardiac mortality and effects of drugs

 

Researchers conducted follow-up studies using a research cohort of nurse health studies and health professionals, and followed up eligible participants (100,300 women and 47,991 men) for up to 24 years
.

And use the Cox proportional hazard model to estimate the hazard ratio and 95% confidence interval

 

During the follow-up, the researchers recorded a total of 2,924 CRC cases
.

In a fully adjusted analysis, the longer the use of statins, the higher the risk of colon cancer (compared with never users, the risk ratio of 1-5 years of use of statins is 1.

Colon cancer

The findings of this study do not support the benefits of statins in CRC chemoprevention, nor do they support any association between total cholesterol levels and CRC risk
.

On the contrary, long-term use of statins may be associated with an increased risk of colon cancer

The findings of this study do not support the benefits of statins in CRC chemoprevention, nor do they support any association between total cholesterol levels and CRC risk

Zhang, Yin.

Long-Term Statin Use, Total Cholesterol Level, and Risk of Colorectal Cancer: A Prospective Cohort Study.
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