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Neuropsychiatric symptoms (NPS) are very common in the cognitive function spectrum of the elderly.
Neuropsychiatric symptoms (NPS) are very common in the cognitive function spectrum of the elderly.
Apathy , defined as reduced motivation and goal-oriented behavior, is the most common neuropsychiatric symptom in the subtype of dementia, and is usually described as a manifestation of "indifference.
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ShutterstockAccording to reports, up to 72% of Alzheimer's (AD ) patients are indifferent.
It is reported that up to 72% of Alzheimer’s patients (AD reported that up to 72% of Alzheimer’s (AD ) patients have apathy.
At the same time, there is evidence that patients with mild cognitive impairment and apathy have a higher risk of dementia.
The relationship between the degree of indifference and the cumulative risk of dementia during follow-up.
The relationship between the degree of indifference and the cumulative risk of dementia during follow-up.
Apathy increases with the pathological severity of dementia , and apathy increases with the pathological severity of dementia.
The researchers designed a cross-sectional case-control study that included participants from 58 clinical centers in Phase 2 of the Alzheimer's Disease Neuroimaging Program (ADNI2) in the United States and Canada.
Results A total of 407 participants were included, of which 23.
Compared with non-indifferent participants, the apathetic group tended to have lower cognitive scores, more AD rather than MCI, that is, more severe cognitive impairment.
Cortical areas of interest related to apathy in cognitively impaired participants.
Cortical areas of interest related to apathy in cognitively impaired participants.
Compared with the non-indifferent group, the right medial orbitofrontal cortex (mOFC) and left anterior cingulate cortex (rACC) of the apathetic group were thinner, while the left middle temporal gyrus (MTC) was thicker.
Indifference is not only independently linked to increased risk of dementia, but also affects changes in brain structure.
references:
Structural Brain Differences Between Cognitively Impaired Patients With and Without Apathy.
https://doi.
org/10.
1016/j.
jagp.
2020.
12.
008
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