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    Home > Active Ingredient News > Study of Nervous System > AJP: Vitamin A analogues may help treat diabetic retinopathy

    AJP: Vitamin A analogues may help treat diabetic retinopathy

    • Last Update: 2020-06-16
    • Source: Internet
    • Author: User
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    June 13, 2020 /PRNewswire/ -- Biovalley BIOON/--- Diabetic retinopathy is a common complication of diabetes and a major cause of blindness in adultsA new study published in the journal American Journal of Pathology says a single dose of 9-cis-retinall, a vitamin A analogue that forms a visual pigment in retinal cells, significantly improves visual function in mice with diabetes"In earlier studies, we found that diabetes, even before no changes in blood vessels were detected, caused a vitamin A deficiency in the retina, leading to reduced visionThe findings lead to the idea that early vision changes in diabetes may be caused by diabetes," explained DrGennadiy Moiseyev of the Department of Physiology, Department of Physiology, University of Oklahoma Health Science Center(Photo source:In the current study, researchers speculated that treating diabetic mice with 9-cis-retinal could restore visual functionThey studied their role in mice with type 1 diabetes by measuring retinal electrogram (ERG) reactions, retinal oxidative stress, and neuronapop (cell death)The results showed a significant improvement in visual function in diabetic mice after single dose 9-shun-retinathe therapyIn addition, the researchers report that the treatment reduces oxidative stress in the retina, reduces retinal cell death and retinal degeneration, and improves visual functionDr Moiseyev commented: "This work supports our new hypothesis that diabetes-induced vitamin A metabolic disorders in the eye are responsible for the decline in early visual function of diabetic retinopathyThere is currently no treatment to prevent the development of retinal complications in diabetic patientsThe study showed that treating the eye of diabetics with these drugs could save the patient's eyesight by preventing the onset of disease at an early stage"( Source: A vitamin A A analog may help treat pecan retinopathy original source: Volha VMalechka et al, The Administration of a Chromophore Rasras Strus Defects in Retinopathy, The American Journal of The DOI: 10.1016/j.ajpath.2020.03.009
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