Akirin2 is specific to the nervous system in the development of African claw frogs.

The development of vertebrate nervous system includes three main processes: nerve induction, pattern formation and neural differentiation.
neuro-induced formation of nerve plates consists of a variety of neuroresurgery cells that specificate the expression of transcription factor Sox2 in order to maintain their cellular plurity.
in the neurodifferentiation phase, sox2 expression in neuro presupgeral cells is reduced, activating the Nngr1---NeuroD1---N-tubulin path, which initiates the differentiation process of neurons.
Xiaoliang and Xia Yingjie (co-first author, graduated) of the Neurodevelopmental and Evolutionary Group of the Kunming Institute of Zoology of the Chinese Academy of Sciences have found that Akirin2 is specific to the nervous system in the development of African claw frogs.
, Akirin2 was involved in the maintenance of early neuro prescient cells in African claw frogs and the regulation of neuron differentiation processes.
further bio-chemical experiments have shown that Akirin2 is involved in the regulation of neurogenic cell maintenance and neuron differentiation processes by participating in different protein complexes. In neuroresurgery cells, Akirin2 interacts with the sub-base BAF53a of the BAF chromatin remodeling complex and its interoperability factor Gemin, antagonizing Gemin's expression induction to Sox2 in order to maintain the appropriate number of neuroresexual cells;
was published online February 13 in the Journal of Biochemistry.
first reported on the function of highly conservative Akirin2 in vertebrates to regulate early nervous system development and its molecular mechanisms.
Researcher Mao Yu and Assistant Researcher Ma Pengcheng are co-authors of the article.
the study was funded by the National Natural Science Foundation of China.
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