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Introduction Recently, Hepatology (impact factor 14.
679) published a study to evaluate the effect of alcohol and body mass index (BMI) on the cumulative incidence of cirrhosis (defined as the first hospitalization due to cirrhosis)
.
The results show that alcohol intake and obesity are independent risk factors for the onset of liver cirrhosis, but the combination of the two has no more significant effect
.
The study method included 489,285 subjects from the British Biobank.
The main outcome was the cumulative incidence of cirrhosis, which was defined as the first hospitalization due to cirrhosis, and the 10-year cumulative incidence of the included subjects was calculated
.
Divide BMI into 4 levels: <20 kg/m2, 20-25.
0 kg/m2, 25.
0 -30 kg/m2, and ≥30 kg/m2, among which subjects with a BMI of 20-25.
0 kg/m2 are considered "Healthy" BMI population
.
Alcohol intake is divided into 3 levels: safe drinking (men’s weekly intake <22 U, women <15 U), dangerous drinking (men’s weekly intake is 22-49 U, women’s 15-35 U) ) And harmful drinking (a weekly intake of men> 50 U, women> 35 U)
.
The results of the study were followed up for an average of 10.
7 person-years, and the main outcome occurred in 2,070 subjects
.
The average age of the subjects was 57.
0 years old, of which 45.
4% were men
.
The cumulative incidence of liver cirrhosis increases with alcohol intake
.
The 10-year cumulative incidence of liver cirrhosis in harmful drinkers is 5 times higher than that in safe drinkers (1.
51% vs.
0.
30%)
.
However, this ratio varies with BMI
.
Among people with healthy BMI, the 10-year cumulative incidence of cirrhosis in harmful drinkers is 8.
6 times that of safe drinkers (1.
38% vs.
0.
16%)
.
In contrast, among obese people, the 10-year cumulative incidence of liver cirrhosis in harmful drinkers is only 3.
6 times that of safe drinkers (1.
99% vs.
0.
56%) (Figure 1)
.
Figure 1 According to BMI stratification, the cumulative incidence of liver cirrhosis with different alcohol intake The cumulative incidence of liver cirrhosis varies greatly with BMI
.
The 10-year cumulative incidence of obese people is 3.
1 times that of healthy people with BMI (0.
65% vs.
0.
21%)
.
However, the ratio varies greatly with alcohol intake
.
When alcohol intake is at a safe level, the 10-year cumulative incidence of obese people is 3.
7 times that of healthy people with BMI (0.
56% vs.
0.
15%)
.
Among harmful drinkers, the 10-year cumulative incidence of obese people is only 1.
4 times higher than that of healthy people with BMI (1.
99% vs.
1.
38%) (Figure 2)
.
Figure 2 According to the stratification of alcohol intake, the study on the cumulative incidence of liver cirrhosis with different BMIs concluded that alcohol intake and obesity are independent risk factors for the onset of liver cirrhosis, but the combination of the two has no more significant effect
.
References: [1] Innes H, Crooks CJ, Aspinall E, et al.
Characterising the risk interplay between alcohol intake and body mass index on cirrhosis morbidity[J].
Hepatology.
2021 Aug 28.
doi: 10.
1002/hep.
32123.
[2] Kling J.
How Do Alcohol, Obesity Impact Cirrhosis? Medscape.
2021 Sep 23.
679) published a study to evaluate the effect of alcohol and body mass index (BMI) on the cumulative incidence of cirrhosis (defined as the first hospitalization due to cirrhosis)
.
The results show that alcohol intake and obesity are independent risk factors for the onset of liver cirrhosis, but the combination of the two has no more significant effect
.
The study method included 489,285 subjects from the British Biobank.
The main outcome was the cumulative incidence of cirrhosis, which was defined as the first hospitalization due to cirrhosis, and the 10-year cumulative incidence of the included subjects was calculated
.
Divide BMI into 4 levels: <20 kg/m2, 20-25.
0 kg/m2, 25.
0 -30 kg/m2, and ≥30 kg/m2, among which subjects with a BMI of 20-25.
0 kg/m2 are considered "Healthy" BMI population
.
Alcohol intake is divided into 3 levels: safe drinking (men’s weekly intake <22 U, women <15 U), dangerous drinking (men’s weekly intake is 22-49 U, women’s 15-35 U) ) And harmful drinking (a weekly intake of men> 50 U, women> 35 U)
.
The results of the study were followed up for an average of 10.
7 person-years, and the main outcome occurred in 2,070 subjects
.
The average age of the subjects was 57.
0 years old, of which 45.
4% were men
.
The cumulative incidence of liver cirrhosis increases with alcohol intake
.
The 10-year cumulative incidence of liver cirrhosis in harmful drinkers is 5 times higher than that in safe drinkers (1.
51% vs.
0.
30%)
.
However, this ratio varies with BMI
.
Among people with healthy BMI, the 10-year cumulative incidence of cirrhosis in harmful drinkers is 8.
6 times that of safe drinkers (1.
38% vs.
0.
16%)
.
In contrast, among obese people, the 10-year cumulative incidence of liver cirrhosis in harmful drinkers is only 3.
6 times that of safe drinkers (1.
99% vs.
0.
56%) (Figure 1)
.
Figure 1 According to BMI stratification, the cumulative incidence of liver cirrhosis with different alcohol intake The cumulative incidence of liver cirrhosis varies greatly with BMI
.
The 10-year cumulative incidence of obese people is 3.
1 times that of healthy people with BMI (0.
65% vs.
0.
21%)
.
However, the ratio varies greatly with alcohol intake
.
When alcohol intake is at a safe level, the 10-year cumulative incidence of obese people is 3.
7 times that of healthy people with BMI (0.
56% vs.
0.
15%)
.
Among harmful drinkers, the 10-year cumulative incidence of obese people is only 1.
4 times higher than that of healthy people with BMI (1.
99% vs.
1.
38%) (Figure 2)
.
Figure 2 According to the stratification of alcohol intake, the study on the cumulative incidence of liver cirrhosis with different BMIs concluded that alcohol intake and obesity are independent risk factors for the onset of liver cirrhosis, but the combination of the two has no more significant effect
.
References: [1] Innes H, Crooks CJ, Aspinall E, et al.
Characterising the risk interplay between alcohol intake and body mass index on cirrhosis morbidity[J].
Hepatology.
2021 Aug 28.
doi: 10.
1002/hep.
32123.
[2] Kling J.
How Do Alcohol, Obesity Impact Cirrhosis? Medscape.
2021 Sep 23.