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    Home > Biochemistry News > Biotechnology News > "Alien" changes in the fungus lead to immune escape events

    "Alien" changes in the fungus lead to immune escape events

    • Last Update: 2022-10-01
    • Source: Internet
    • Author: User
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    Microscopic imaging experiments developed by Olivier et al.
    captured the escape
    of fungi (Candida albicans) from immune cells (macrophages).
    Left: Fungi inside immune cells (red
    ).
    Right: Fugitive hyphae (blue) and nuclei of dead immune cells (green
    ).


    Fungal pathogens have significant global implications for human health – they are often difficult to diagnose and treat, making there an urgent need for better diagnosis and more effective antifungal treatment
    .


    The paper, published in Cell Reports, led by Professor Ana Traven and doctoral student Françios Olivier, describes how Candida albicans uses sword-like filaments to contact toxin molecules and disrupt immune cell membranes in the cell death pathway, allowing it to escape and spread
    .


    This imaging technology, developed by Olivier in collaboration with Monash Microimaging, can pinpoint escaped fungi
    in real time.


    Candida is a yeast that often lives in the digestive tract and oral tract of humans, as well as urinary and reproductive organs
    .


    Professor Traven said targeting fugitive fungi "offers a promising therapeutic pathway that both prevents the spread of infection and has the potential to inhibit inflammation"
    .


    The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

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