AlimentaryYY Therapeutics: Helicobacter pylori infection reduces the incidence of adenocarcinoma in the esophagus and near end of the stomach

BACKGROUND: Hpylori infection is the most important risk factor for non-late-end gastric adenocarcinoma, but some people think it has a protective effect on esophageal adenocarcinoma and near-end stomach cancerTherefore, the purpose of this study is to assess the risk of treating and eradicating Helicobacter pylori that alters the esophagus and near-end stomach cancermethod: Researchers reviewed 36,803 patients diagnosed with Helicobacter pylori at the U.SVeterans Administration between January 1, 1994 and December 31, 2018, with a median age of 60.4 years and 91.8 percent of menThe main result is the diagnosis of esophagus and near-end stomach cancerAssess patient factors and whether the patient is receiving Helicobacter pylori treatmentresults: 5 years after diagnosis of Helicobacter pylori, 10 and 15 years of cumulative incidence of esophageal and near-end gastric cancer was 0.145%, 0.26% and 0.34%, respectivelyThe risk of esophageal or near-end gastric cancer was similar between whites (reference), African-Americans (SHR 0.87, 95% CI 0.57-1.43) and Amerindians (SHR 1.31, 95% CI 0.18-9.60), but this proportion of Asians was significantly reduced (P.001)Age increase (SHR 1.17,95% CI every 5 years: 1.09-1.25, P 0.001) and smoking (SHR 2.06, 95% CI: 1.33-3.18, P-0.001) are associated with esophageal and near-end gastric cancerConclusion: This study proves that the incidence of gastric cancer decreased after esophagus and near-end gastric therapyOlder people and smoking are associated with future cancers, while Asian or Native Hawaiian races have a protective effect