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House dust mite (HDM) is the main cause of allergic rhinitis and asthma.
Although more than 30 HDM-derived allergens have been identified so far, the specific treatment method has not taken into account the local sensitization characteristics of the patient.
Recently, researchers have determined the HDM sensitization patterns of adults with HDM allergies living in different geographic regions, providing information for the development of targeted diagnostic and treatment tools.
The study included serum samples from 685 subjects with HDM allergies from Canada, Europe, South Africa, and the United States, and tested specific IgE levels.
The results of the study showed that there are significant regional differences in allergy patterns and IgE levels.
In all regions, the main allergens are group 1 and group 2 allergens and Der p 23.
Der p 23 is a common allergen: 64% of subjects have specific IgE to Der p 23, and 2.
3% of subjects have a single sensitization to Der p 23.
In South Africa, Der p 23 is the major HDM allergen (86% prevalence), and Der p 7 has reached the major allergen status (56%).
The sensitivity of IgE to HDM is affected by asthma status, allergen exposure level, age, ethnicity, and smoking status, but is not affected by BMI.
The IgE response frequency of HDM allergens based on regions and research groups.
Finally, the researchers pointed out that in South Africa, Der p 7 and Der p 23 are the main allergens, and HDM allergen sensitivity is different in different regions.
This heterogeneity should be considered when diagnosing and treating patients with HDM allergies.
Original source: Varun Muddaluru, Rudolf Valenta, Susanne Vrtala et al.
Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA.
Allergy.
Jan 2021 For more information, please click to read the original text Download Metz Medical APP~
Although more than 30 HDM-derived allergens have been identified so far, the specific treatment method has not taken into account the local sensitization characteristics of the patient.
Recently, researchers have determined the HDM sensitization patterns of adults with HDM allergies living in different geographic regions, providing information for the development of targeted diagnostic and treatment tools.
The study included serum samples from 685 subjects with HDM allergies from Canada, Europe, South Africa, and the United States, and tested specific IgE levels.
The results of the study showed that there are significant regional differences in allergy patterns and IgE levels.
In all regions, the main allergens are group 1 and group 2 allergens and Der p 23.
Der p 23 is a common allergen: 64% of subjects have specific IgE to Der p 23, and 2.
3% of subjects have a single sensitization to Der p 23.
In South Africa, Der p 23 is the major HDM allergen (86% prevalence), and Der p 7 has reached the major allergen status (56%).
The sensitivity of IgE to HDM is affected by asthma status, allergen exposure level, age, ethnicity, and smoking status, but is not affected by BMI.
The IgE response frequency of HDM allergens based on regions and research groups.
Finally, the researchers pointed out that in South Africa, Der p 7 and Der p 23 are the main allergens, and HDM allergen sensitivity is different in different regions.
This heterogeneity should be considered when diagnosing and treating patients with HDM allergies.
Original source: Varun Muddaluru, Rudolf Valenta, Susanne Vrtala et al.
Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA.
Allergy.
Jan 2021 For more information, please click to read the original text Download Metz Medical APP~
