Almost everyone has taken this medicine, more than 10-15g can cause death. These commonly used drugs in families can cause liver damage

Liver is a unique immune organ, which contains a large number of natural immune cells and acquired immune cells, and can induce a variety of complex and fine immune responses The liver is also a metabolic organ, which is in charge of sugar, fat, detoxification and metabolism Most of the metabolism of human body and the transformation of toxic substances, so it is also one of the most vulnerable organs Among the existing liver damage factors, the damage caused by hepatotoxic drugs cannot be ignored Drug induced liver injury (DILI) refers to the toxic damage of hepatocytes caused by drugs and / or their metabolites, or the disease caused by the allergic reaction of drugs and their metabolites, which can be clinically manifested as acute / chronic drug-induced hepatitis and drug-induced cirrhosis The risk factors include age, sex, nutritional status, heredity, drug dosage and course of treatment, combined medication, alcohol and so on At present, almost all known drugs are metabolized by the liver, so the liver becomes the main target organ of drug-induced diseases According to the different pathogenesis of Dili, it can be divided into predictable type and unpredictable type: all kinds of prescription or over-the-counter chemical drugs, biological agents, traditional Chinese medicine, natural drugs, health care products, dietary supplements and their metabolites and accessories can induce liver injury In foreign countries, antipyretic and analgesic drugs, antibiotics, anticonvulsant drugs and psychotropic drugs are common drugs causing Dili; in China, Chinese herbal medicine, antituberculosis drugs and health nutrition products are more common According to foreign epidemiological data, the incidence of Dili accounts for 10% - 15% of all adverse drug reactions, which is also the main reason for the failure or withdrawal of drug clinical trials In the past half century, the drugs withdrawn from the market due to hepatotoxicity include isopropylniazid, bromofenac, troglitazone, etc Among the drugs approved for marketing, isoniazid, rabeprolol and trafloxacin are also restricted due to their hepatotoxicity At present, more than 1100 kinds of drugs are known to have potential hepatotoxicity in the global market, among which there are many drugs that we are very familiar with The most representative paracetamol is acetaminophen (APAP), which has antipyretic and analgesic effects Many cold medicines on the market contain APAP, including Gankang, kangbide, Baijiahei, Sanlitong, bilitong, Tylenol, tenolin, express, 999 Ganmaoling, VEC Yinqiao tablet, Ganmaoqing capsule, etc If taking many kinds of cold drugs at the same time, the total dose of APAP has been greatly exceeded unconsciously When the maximum daily dose is more than 4G, it can cause liver damage, and more than 10-15g can cause acute liver failure or even death In addition to the daily cold medication, the side effects of traditional Chinese herbal medicine, which is highly praised by the people, are also thought-provoking With the extensive application of Chinese herbal medicine and the in-depth study of its toxicology at home and abroad, more and more cases of liver damage caused by Chinese herbal medicine have been found At present, more than 100 kinds of Chinese herbal medicines and more than 30 kinds of Chinese patent medicines have been found to cause liver damage, involving medicines such as xanthate, Tripterygium wilfordii, Polygonum multiflorum, indigo naturalis, Shandou root, Yudan, Yinyanghuo, Aristolochia, xanthate, bupleurum, Xanthium sibiricum, Guanmutong, chrysanthemum notoginseng, smallpox, clove, etc The common drugs that can cause liver injury are often used as antibacterial drugs in the family medicine cabinet Because they are often used, their harmfulness is easy to be ignored According to the investigation data of Dili, the serious drug-induced liver injury is mostly caused by antibiotics, especially penicillins and cephalosporins However, this does not mean that the incidence of Dili caused by antibiotics is high, but compared with other drugs, the use of antibiotics is higher, so there are more cases According to the following data, the liver damage caused by natural penicillin is rare, and the liver damage caused by other antibiotics is relatively more Note: This article is the original manuscript of the author of yaozhi.com, welcome to reprint, please indicate the source and author when reprint, thank you!