Alz Res Therapy: Novel Single-Cell Marker Predicts Changes in Cognitive Function

The decline in cognitive function in old age is one of the most important public health challenges in the coming decades

Immune dysregulation, characterized by chronic and exacerbated glial polarization , contributes to cognitive decline by promoting neurodegeneration (synaptic loss and neuronal death)

Although animal- and human-based studies have linked increased CSF and plasma levels of MCP-1 to functional and brain structural changes associated with cognitive decline in older adults, previous studies have been mostly cross-sectional, including healthy subjects or People diagnosed with dementia

Therefore, Juan Luis Sanchez‑Sanchez et al.

They included 1097 subjects (mean age = 75.

Use consecutive MCP-1 and dichotomies (the highest quartile value (MCP-1+)), and Aβ42/40 dichotomies

They found that plasma MCP-1, as a continuous variable, was associated with memory deterioration over the 4-year follow-up, particularly in measures of free and cued delayed recall

MCP-1+ vs CCS (4-year between-group difference: β=-0.

In domain-specific analyses, MCP-1+ was associated with declines in the delayed recall subdomain of FCSRT