Alz Res Therapy: White matter hyperintensity and dementia imaging indicators are inextricably linked

White matter hyperintensity (WMH), quantified using (FLAIR) magnetic resonance imaging (MRI), is considered to be a sign of cerebrovascular disease and is closely related to age and cardiovascular risk factors
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The existence of WMH is also associated with lower cognitive ability and increased risk of clinical Alzheimer's disease (AD), which indicates that WM injury is involved in the pathogenesis of AD

Vascular Cardiovascular

Previous studies have shown that using sensitive PET, cerebrospinal fluid (CSF) or magnetic resonance imaging (MRI) biomarkers measurement, WM pathology may be related to β-amyloid (Aβ) plaques, tau tangles, and pathological signs of neurodegeneration Things are directly related
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Therefore, in some cross-sectional studies, the greater presence and extension of WMH is associated with greater Aβ deposition, although there is no consistent finding, and in brain regions normally affected by AD, glucose metabolism is lower and gray matter volume (GMV) Reduce

In the existing literature, global WMH descriptors are often used to quantify WM pathology and assess its relationship with AD brain biomarkers
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This method masks the influence of a specific area

A total of 155 participants (IMAP+ cohort), from normal cognition to AD dementia, received FLAIR MRI, AV45-PET, FDG-PET and T1 MRI
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Automatically segment WMH from FLAIR images

They found that there is no obvious connection between the global Aβ burden and the WMH in a specific area
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The voxel WMH in the corpus callosum is associated with greater Aβ deposition below the threshold

There is no obvious connection between the global Aβ burden and the WMH in a specific area

Similarly, the decrease in medial-temporal GMV is associated with WMH in the posterior part of the corpus callosum and WMH in the parietal, occipital, and frontal regions
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This study shows that local white matter damage is associated with multimodal brain biomarkers of AD
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This result emphasizes the pattern-specific distribution patterns of WMH, which converge in the posterior white matter

This result emphasizes the pattern-specific distribution patterns of WMH, which converge in the posterior white matter

Original source:

Gaubert M, Lange C, Garnier-Crussard A, et al.

Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease.
Alz Res Therapy.

Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease.

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