Alzheimer&Dementia: Cancer is not evil, it can actually reduce the risk of dementia!

Some epidemiological studies have found that cancer has a protective effect on dementia, especially Alzheimer's disease (AD)
.

Similarly, a prospective cohort study in the UK estimated that cancer not only reduces any risk of AD-related dementia, but also reduces future cancer risk by 70%

Cancer not only reduces the risk of any dementia associated with AD, but also reduces the risk of future cancer by 70%

For example, although a recent national Danish cohort study also showed that cancer initially had a protective effect on AD, the intensity of this effect decreased over time

Screening

In order to comprehensively analyze the relationship between cancer and dementia risk, experts from the Bordeaux Population Health Research Center in France conducted a meta-analysis and the results were published in the journal Alzheimer & Dementia
.

This study used data from the Memento cohort, a French multicenter cohort that followed people with mild or isolated cognitive impairment for a median of 5 years
.

Use disease-death models (IDMs) to estimate transitional specific risk ratios (HRs) and 95% confidence intervals (CIs) for cancers related to dementia since entering the study

The researchers analyzed the sample (N = 2258) and excluded 65 people who had no follow-up information
.

At the end of the follow-up, 286 people were diagnosed with dementia, 166 people were diagnosed with cancer, and 95 people died

Diagnosis Overall, cancer is associated with a 42% reduction in the risk of dementia (HR=0.

The relationship between cancer and all risks of dementia and AD

Compared with the less restrictive outcome definition (which includes all cases of dementia, regardless of the cause), the impact of cancer on the intensity of the transition to AD dementia is increasingly protective
.

There is no evidence that there is an interaction between cancer and other covariates, especially with APOE ε4 allele carriers (P = 0.

The incidence of cancer is associated with an increase in the intensity of the transition from health to death (HR=3.

In summary, this research supports the protective relationship between cancer and dementia and encourages further investigations to understand the underlying mechanisms

references:

references:

Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.

Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.

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